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QuickView for RARS2;jsessionid=BE3E688A595EC75BA9590A24192A7C9C (gene)


Gene Symbol:
RARS2 Homo sapiens Homo sapiens
Full name:
arginyl-tRNA synthetase 2, mitochondrial
Synonyms:
ArgRS, DALRD2, PCH6, PRO1992, RARSL, probable arginine--tRNA ligase, mitochondrial, probable arginyl-tRNA synthetase, mitochondrial
Genomic Location:
Chr 6: 88280820-88356440
Description:
This nuclear gene encodes a protein that localizes to the mitochondria, where it catalyzes the transfer of L-arginine to its cognate tRNA, an important step in translation of mitochondrially-encoded proteins. Defects in this gene are a cause of pontocerebellar hypoplasia type 6 (PCH6). Alternative splicing results in multiple transcript variants.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6q15





GO Molecular Function

arginine-tRNA ligase activity | nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | catalytic activity | aminoacyl-tRNA ligase activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | ligase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding | RNA binding

GO Biological Process

RNA metabolic process | arginyl-tRNA aminoacylation | tRNA aminoacylation | cellular process | cellular amino acid metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | peptide biosynthetic process | mitochondrial translation | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | nitrogen compound metabolic process | small molecule metabolic process | cellular amide metabolic process | tRNA aminoacylation for protein translation | translation | biosynthetic process | peptide metabolic process | carboxylic acid metabolic process | tRNA metabolic process | protein metabolic process | metabolic process | mitochondrial gene expression | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | amide biosynthetic process | organic acid metabolic process | cellular protein metabolic process | cellular macromolecule biosynthetic process | ncRNA metabolic process | heterocycle metabolic process | cellular metabolic process | macromolecule metabolic process

GO Cellular Component

mitochondrial matrix | intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | organelle | membrane-enclosed lumen | intracellular