QuickView for RBBP6;jsessionid=BE3E688A595EC75BA9590A24192A7C9C (gene)

Gene Symbol:

RBBP6 Homo sapiens

Full name:

RB binding protein 6, ubiquitin ligase

Synonyms:

MY038, P2P-R, PACT, RBQ-1, SNAMA, E3 ubiquitin-protein ligase RBBP6, RB-binding Q-protein 1, RING-type E3 ubiquitin transferase RBBP6, p53-associated cellular protein of testis, proliferation potential-related protein, protein P2P-R, retinoblastoma binding protein 6, retinoblastoma-binding Q protein 1, retinoblastoma-binding protein 6

Genomic Location:

Chr 16: 24458409-24491685

Description:

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively sp...

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The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  DR3_Q4 ,  USF_Q6 ,  ARNT_01 ,  VDR_Q3 ,  ATGTCAC_MIR489 ,  AML_Q6 ,  CACGTG_MYC_Q2 ,  NGFIC_01 ,  VDR_Q6 ,  ARP1_01 ,  ATGTACA_MIR493 ,  AMEF2_Q6 ,  FAC1_01 ,  COUP_01 ,  ATGGYGGA_UNKNOWN ,  EGR2_01 ,  E2F1_Q4 ,  GTACAGG_MIR486 ,  MYAATNNNNNNNGGC_UNKNOWN ,  AR_Q6 ,  TGTATGA_MIR4853P ,  GTGACGY_E4F1_Q6 ,  LFA1_Q6 ,  DR1_Q3 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  YKACATTT_UNKNOWN ,  USF_01 ,  RACCACAR_AML_Q6 ,  RNGTGGGC_UNKNOWN ,  NMYC_01 ,  SCGGAAGY_ELK1_02 ,  CP2_02 ,  COUP_DR1_Q6 ,  ZIC2_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  PPAR_DR1_Q2 ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  EGR3_01 ,  PAX4_01 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

16p12.1

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