QuickView for RBPJ;jsessionid=CEEF0A028C9D537A47EF2A4EB245F2F2 (gene)
- Gene Symbol:
- RBPJ
Homo sapiens - Full name:
- recombination signal binding protein for immunoglobulin kappa J region
- Synonyms:
- AOS3, CBF1, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH, csl, recombining binding protein suppressor of hairless, CBF-1, H-2K binding factor-2, RBP-J kappa, RBP-JK, immunoglobulin kappa J region recombination signal binding protein 1, renal carcinoma antigen NY-REN-30, suppressor of hairless homolog
- Genomic Location:
- Chr 4: 25930430-26042376
- Description:
-
The protein encoded by this gene is a transcriptional regulator important in the Notch signaling pathway. The encoded protein acts as a repressor when not bound to Notch proteins and an activator when bound to Notch proteins. It is thought to function by recruiting chromatin remodeling complexes containing histone deacetylase or histone acetylase p...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
4p15.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | repressing transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | catalytic activity | chromatin binding | protein N-terminus binding | RNA polymerase II repressing transcription factor binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | recombinase activity | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | positive regulation of transcription from RNA polymerase II promoter in response to hypoxia | brain development | positive regulation of striated muscle cell differentiation | Notch signaling pathway | DNA-templated transcription, initiation | molting cycle | ventricular cardiac muscle tissue morphogenesis | cellular response to decreased oxygen levels | positive regulation of macromolecule biosynthetic process | developmental process involved in reproduction | muscle tissue development | heart trabecula morphogenesis | morphogenesis of an epithelium | somatic stem cell population maintenance | positive regulation of striated muscle tissue development | regulation of cardiac muscle cell differentiation | defense response to other organism | establishment of localization | myeloid cell differentiation | dorsal aorta development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | positive regulation of developmental process | negative regulation of RNA biosynthetic process | regulation of heart growth | cell differentiation | endothelial cell differentiation | respiratory tube development | defense response | nervous system development | interleukin-4 secretion | epithelial to mesenchymal transition | neurogenesis | pulmonary valve development | epithelial to mesenchymal transition involved in endocardial cushion formation | generation of neurons | B cell differentiation | mesenchyme development | blood vessel morphogenesis | regulation of cardiac muscle cell proliferation | pattern specification process | positive regulation of cellular biosynthetic process | cellular process | secretion | cell fate specification | positive regulation of canonical Wnt signaling pathway involved in cardiac muscle cell fate commitment | lymphocyte differentiation | localization | epithelial tube morphogenesis | protein transport | tissue remodeling | heart morphogenesis | reproductive system development | endothelial cell fate specification | immune system development | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | regulation of striated muscle tissue development | macromolecule localization | response to hypoxia | myeloid dendritic cell differentiation | lung epithelium development | positive regulation of nitrogen compound metabolic process | regulation of ephrin receptor signaling pathway | diencephalon development | regulation of canonical Wnt signaling pathway | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | positive regulation of muscle cell differentiation | muscle structure development | ventricular septum morphogenesis | regulation of cellular process | leukocyte activation | regulation of metabolic process | pituitary gland development | organic cyclic compound metabolic process | trabecula morphogenesis | RNA biosynthetic process | epithelium development | cellular aromatic compound metabolic process | ventricular trabecula myocardium morphogenesis | head development | blood vessel endothelial cell differentiation | muscle organ morphogenesis | blood vessel lumenization | response to stimulus | vasculature development | respiratory system development | blood vessel remodeling | cellular response to hypoxia | response to stress | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | tube morphogenesis | cardiac muscle tissue development | muscle tissue morphogenesis | inflammatory response to antigenic stimulus | hair follicle maturation | reproduction | secretion by cell | cardiovascular system development | cardiac ventricle morphogenesis | heart formation | cellular nitrogen compound metabolic process | Clara cell differentiation | inner ear receptor cell differentiation | myeloid dendritic cell activation | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of BMP signaling pathway | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | embryo development | DNA recombination | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus | positive regulation of ERBB signaling pathway | positive regulation of transcription of Notch receptor target | embryonic placenta development | blood vessel development | anterior/posterior pattern specification | neuron fate commitment | hair cell differentiation | regulation of nucleic acid-templated transcription | leukocyte differentiation | endocardial cushion development | epithelial cell fate commitment | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | reproductive process | regulation of signal transduction | endothelium development | interleukin-4 production | multicellular organism development | regulation of BMP signaling pathway | inner ear auditory receptor cell differentiation | neuroepithelial cell differentiation | positive regulation of muscle organ development | negative regulation of cold-induced thermogenesis | regulation of ossification | mechanoreceptor differentiation | cardiac epithelial to mesenchymal transition | artery development | regulation of gene expression | outflow tract morphogenesis | organic substance transport | cellular response to stress | endocardial cushion morphogenesis | myeloid leukocyte differentiation | auditory receptor cell fate commitment | positive regulation of cellular metabolic process | animal organ morphogenesis | epidermal cell fate specification | specification of animal organ identity | positive regulation of Notch signaling pathway | cellular response to oxygen levels | regulation of nitrogen compound metabolic process | placenta blood vessel development | regulation of Notch signaling pathway | peptide transport | cardiocyte differentiation | regulation of transcription by RNA polymerase II | positive regulation of cell differentiation | epidermal cell differentiation | stem cell differentiation | B cell activation | regulation of cell proliferation involved in heart morphogenesis | biosynthetic process | positive regulation of cardiac muscle cell proliferation | labyrinthine layer development | aromatic compound biosynthetic process | positive regulation of transcription from RNA polymerase II promoter in response to stress | angiogenesis | mesenchyme morphogenesis | cardiac septum morphogenesis | epidermis development | labyrinthine layer blood vessel development | skin development | endocrine system development | keratinocyte differentiation | sensory organ development | response to bacterium | regulation of timing of cell differentiation | chordate embryonic development | animal organ formation | striated muscle tissue development | peptide secretion | cardiac muscle tissue morphogenesis | cell communication | regulation of cellular metabolic process | semi-lunar valve development | arterial endothelial cell fate commitment | humoral immune response | inflammatory response | recombinase activity | positive regulation of signal transduction | inner ear development | heart development | defense response to bacterium | positive regulation of cell proliferation | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of cellular response to growth factor stimulus | lymphocyte activation | lung epithelial cell differentiation | neuron differentiation | cytokine production | positive regulation of organ growth | heart valve development | ventricular septum development | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | regionalization | cardiac ventricle development | regulation of growth | hair cycle | gland development | regulation of cardiac muscle tissue development | tissue morphogenesis | artery morphogenesis | endocardium development | DNA metabolic process | regulation of animal organ morphogenesis | negative regulation of ossification | endocardium morphogenesis | ventricular cardiac muscle tissue development | anatomical structure development | cell surface receptor signaling pathway | aorta development | endothelial tube morphogenesis | metabolic process | cell fate commitment | mesenchymal cell differentiation | cytokine secretion | dendritic cell differentiation | regulation of DNA-templated transcription in response to stress | regulation of RNA biosynthetic process | developmental maturation | negative regulation of transcription, DNA-templated | embryonic organ development | positive regulation of ephrin receptor signaling pathway | ear development | amide transport | hair cycle process | heart field specification | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | atrioventricular canal development | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | gene expression | dorsal aorta morphogenesis | regulation of heart morphogenesis | skin epidermis development | regulation of Wnt signaling pathway | regulation of striated muscle cell differentiation | establishment of protein localization | positive regulation of muscle tissue development | transcription initiation from RNA polymerase II promoter | transcription, DNA-templated | cell activation | aorta morphogenesis | lung development | positive regulation of canonical Wnt signaling pathway | anatomical structure formation involved in morphogenesis | positive regulation of cardiac muscle cell differentiation | positive regulation of cell proliferation involved in heart morphogenesis | regulation of cell communication | positive regulation of developmental growth | signaling | somite development | positive regulation of growth | regulation of transcription, DNA-templated | myoblast differentiation | regulation of ERBB signaling pathway | regulation of developmental growth | protein localization | regulation of transcription from RNA polymerase II promoter in response to stress | cardioblast differentiation | endocardial cushion formation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | regulation of organ growth | response to biotic stimulus | reproductive structure development | regulation of developmental process | regulation of transcription from RNA polymerase II promoter in response to hypoxia | segmentation | developmental process | arterial endothelial cell differentiation | regulation of muscle cell differentiation | lung cell differentiation | cardiac septum development | negative regulation of transcription by RNA polymerase II | tube development | positive regulation of transcription, DNA-templated | aortic valve development | negative regulation of cell proliferation | cardiac muscle cell myoblast differentiation | positive regulation of nucleic acid-templated transcription | regulation of development, heterochronic | positive regulation of heart growth | epithelial cell differentiation | positive regulation of transcription by RNA polymerase II | positive regulation of cell fate commitment | secondary heart field specification | cardiac chamber development | heterocycle metabolic process | somitogenesis | regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation | regulation of cell fate commitment | central nervous system development | in utero embryonic development | positive regulation of metabolic process | immune system process | positive regulation of Wnt signaling pathway | cellular metabolic process | hematopoietic or lymphoid organ development | sebaceous gland development | placenta development | positive regulation of cardiac muscle tissue development | protein secretion | circulatory system development | negative regulation of cell differentiation | blood vessel endothelial cell fate specification | muscle organ development | response to other organism | positive regulation of signaling | cardiac left ventricle morphogenesis | hair follicle development | signal transduction | regulation of signaling | Notch signaling involved in heart development | positive regulation of gene expression | regulation of muscle organ development | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | membrane-enclosed lumen | MAML1-RBP-Jkappa- ICN1 complex | intracellular
