QuickView for REST;jsessionid=BE0D63F12B7593106BAA6E012C1D62C1 (gene)
- Gene Symbol:
- REST
Homo sapiens - Full name:
- RE1 silencing transcription factor
- Synonyms:
- GINGF5, HGF5, NRSF, WT6, XBR, RE1-silencing transcription factor, RE1-silencing transcription factor variant E1a/E2/E3/E4c, RE1-silencing transcription factor variant E1a/E2/E3/E5, RE1-silencing transcription factor variant E1a/E2/E3/N3a/E4i, RE1-silencing transcription factor variant E1a/E2/E3/N3c/E4, RE1-silencing transcription factor variant E1a/E2/E4, RE1-silencing transcription factor variant E1a/E2/E5, RE1-silencing transcription factor variant E1a/E2a/E2k, RE1-silencing transcription factor variant E1a/E2d/E4g, RE1-silencing transcription factor variant E1a/E2e/E4h, RE1-silencing transcription factor variant E1a/E2f/E4e, RE1-silencing transcription factor variant E1a/E2k/E2i/E3/E4j, RE1-silencing transcription factor variant E1b/E2/E3/E5, RE1-silencing transcription factor variant E1b/E2/E3/N3b/E4i, RE1-silencing transcription factor variant E1b/E2/E3/N3c/E4, RE1-silencing transcription factor variant E1b/E2a/E2k, RE1-silencing transcription factor variant E1b/E2c/E2j/E3/E4, RE1-silencing transcription factor variant E1b/E2e/E4h, RE1-silencing transcription factor variant E1c/E2/E3/E5, RE1-silencing transcription factor variant E1c/E2a/E2k, RE1-silencing transcription factor variant E1c/E2g/E3/E4, neural-restrictive silencer factor, neuron restrictive silencer factor, repressor binding to the X2 box
- Genomic Location:
- Chr 4: 57468799-57493097
- Description:
-
This gene encodes a transcriptional repressor that represses neuronal genes in non-neuronal tissues. It is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenito...
- Orthologs:
- Mus musculus , Rattus norvegicus , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
4q12
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | voltage-gated ion channel activity | cation binding | passive transmembrane transporter activity | proximal promoter sequence-specific DNA binding | nucleic acid binding | transmembrane transporter activity | ion gated channel activity | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | histone deacetylase activity | RNA polymerase II regulatory region DNA binding | cation transmembrane transporter activity | DNA binding | sequence-specific double-stranded DNA binding | transporter activity | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | voltage-gated potassium channel activity | transcription regulatory region sequence-specific DNA binding | protein binding | potassium channel activity | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | metal ion transmembrane transporter activity | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | outward rectifier potassium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | deacetylase activity | channel activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding | ion channel activity | heterocyclic compound binding | substrate-specific channel activity
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | negative regulation of dense core granule biogenesis | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | regulation of neurogenesis | negative regulation of peptide secretion | positive regulation of apoptotic process | regulation of cell development | regulation of localization | regulation of programmed cell death | establishment of localization | response to hormone | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | nervous system development | response to drug | histone deacetylation | neurogenesis | negative regulation of protein secretion | voltage-gated ion channel activity | regulation of peptide hormone secretion | generation of neurons | interaction with symbiont | positive regulation of cellular biosynthetic process | cellular process | localization | regulation of steroid hormone biosynthetic process | chromatin organization | passive transmembrane transporter activity | negative regulation of signaling | metal ion transport | immune system development | negative regulation of nucleic acid-templated transcription | negative regulation of lipid biosynthetic process | negative regulation of secretion | regulation of proteolysis | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of hormone secretion | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of cell differentiation | interspecies interaction between organisms | muscle structure development | regulation of cellular process | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | negative regulation of aldosterone biosynthetic process | transmembrane transporter activity | negative regulation of amniotic stem cell differentiation | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | regulation of peptide secretion | response to stimulus | negative regulation of protein transport | ion gated channel activity | regulation of insulin secretion | positive regulation of protein metabolic process | positive regulation of peptidase activity | cellular nitrogen compound biosynthetic process | regulation of cell proliferation | positive regulation of cysteine-type endopeptidase activity | hematopoietic progenitor cell differentiation | negative regulation of glucocorticoid biosynthetic process | positive regulation of proteolysis | cellular nitrogen compound metabolic process | negative regulation of transport | cellular response to organic cyclic compound | regulation of protein transport | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | protein deacetylase activity | regulation of peptide transport | regulation of steroid biosynthetic process | cellular biosynthetic process | macromolecule modification | regulation of steroid metabolic process | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | system development | nitrogen compound metabolic process | negative regulation of secretion by cell | multicellular organism development | regulation of peptidase activity | negative regulation of mesenchymal stem cell differentiation | regulation of catalytic activity | regulation of hormone levels | ion transmembrane transport | regulation of hormone secretion | regulation of neuron differentiation | regulation of gene expression | histone deacetylase activity | response to lipid | cation transmembrane transporter activity | modification of morphology or physiology of other organism | positive regulation of cellular metabolic process | monovalent inorganic cation transport | regulation of aldosterone metabolic process | regulation of ketone biosynthetic process | regulation of nitrogen compound metabolic process | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cardiocyte differentiation | response to corticosteroid | cellular potassium ion transport | regulation of transcription by RNA polymerase II | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ion transmembrane transporter activity | potassium ion transport | positive regulation of hydrolase activity | negative regulation of viral process | stem cell differentiation | biosynthetic process | protein deacetylation | regulation of hormone metabolic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of peptide hormone secretion | cellular response to glucocorticoid stimulus | positive regulation of endopeptidase activity | cellular response to corticosteroid stimulus | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | cellular response to drug | negative regulation by host of viral transcription | regulation of cellular metabolic process | voltage-gated potassium channel activity | regulation of protein metabolic process | heart development | histone H4 deacetylation | regulation of RNA metabolic process | regulation of stem cell differentiation | regulation of lipid biosynthetic process | regulation of viral process | positive regulation of molecular function | negative regulation of exocytosis | cation transmembrane transport | potassium channel activity | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | protein metabolic process | regulation of glucocorticoid biosynthetic process | DNA-binding transcription factor activity | regulation of establishment of protein localization | response to organic substance | metal ion transmembrane transporter activity | regulation of exocytosis | anatomical structure development | voltage-gated cation channel activity | potassium ion transmembrane transporter activity | negative regulation of lipid metabolic process | metabolic process | negative regulation of steroid hormone biosynthetic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | regulation of vesicle-mediated transport | regulation of secretion | positive regulation of cell death | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of neuron differentiation | gene expression | regulation of protein secretion | positive regulation of programmed cell death | negative regulation of stem cell differentiation | inorganic cation transmembrane transport | cellular response to steroid hormone stimulus | transcription, DNA-templated | regulation of regulated secretory pathway | outward rectifier potassium channel activity | modulation by host of viral transcription | cation channel activity | negative regulation of hormone biosynthetic process | regulation of cell communication | transmembrane transport | negative regulation of insulin secretion | covalent chromatin modification | inorganic cation transmembrane transporter activity | regulation of transcription, DNA-templated | response to organic cyclic compound | monovalent inorganic cation transmembrane transporter activity | myoblast differentiation | voltage-gated channel activity | cellular protein metabolic process | cardioblast differentiation | regulation of endopeptidase activity | cation transport | cellular macromolecule biosynthetic process | channel activity | regulation of cortisol biosynthetic process | regulation of cellular ketone metabolic process | regulation of nervous system development | regulation of developmental process | negative regulation of calcium ion-dependent exocytosis | negative regulation of cortisol biosynthetic process | developmental process | organelle organization | negative regulation of steroid metabolic process | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | negative regulation of cell proliferation | cardiac muscle cell myoblast differentiation | positive regulation of nucleic acid-templated transcription | potassium ion transmembrane transport | positive regulation of transcription by RNA polymerase II | cellular response to electrical stimulus | heterocycle metabolic process | response to electrical stimulus | regulation of calcium ion-dependent exocytosis | ion channel activity | regulation of viral transcription | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | ion transport | immune system process | cellular metabolic process | regulation of glucocorticoid metabolic process | hematopoietic or lymphoid organ development | regulation of mesenchymal stem cell differentiation | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to steroid hormone | negative regulation of cell development | circulatory system development | substrate-specific channel activity | negative regulation of viral transcription | negative regulation of cell differentiation | negative regulation of steroid biosynthetic process | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of hormone biosynthetic process | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | histone methyltransferase complex | protein-containing complex | methyltransferase complex | nucleoplasm | transferase complex | membrane-bounded organelle | transcriptional repressor complex | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
