QuickView for RET (gene)

Gene Symbol:

RET Homo sapiens

Full name:

ret proto-oncogene

Synonyms:

CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET-ELE1, proto-oncogene tyrosine-protein kinase receptor Ret, RET receptor tyrosine kinase, cadherin family member 12, cadherin-related family member 16, proto-oncogene c-Ret, rearranged during transfection, ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease)

Genomic Location:

Chr 10: 42892523-42945805

Description:

This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differenti...

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This gene encodes a transmembrane receptor and member of the tyrosine protein kinase family of proteins. Binding of ligands such as GDNF (glial cell-line derived neurotrophic factor) and other related proteins to the encoded receptor stimulates receptor dimerization and activation of downstream signaling pathways that play a role in cell differentiation, growth, migration and survival. The encoded receptor is important in development of the nervous system, and the development of organs and tissues derived from the neural crest. This proto-oncogene can undergo oncogenic activation through both cytogenetic rearrangement and activating point mutations. Mutations in this gene are associated with Hirschsprung disease and central hypoventilation syndrome and have been identified in patients with renal agenesis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F4DP1_01 ,  TGTGTGA_MIR377 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  CREBP1_Q2 ,  LEF1_Q2 ,  CTCAGGG_MIR125B_MIR125A ,  ATGCTGC_MIR103_MIR107 ,  ACCAAAG_MIR9 ,  E2F1DP2_01 ,  E2F_03 ,  E2F1DP1_01 ,  TTGCCAA_MIR182 ,  ATF1_Q6 ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F4DP2_01 ,  AAAGGAT_MIR501 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  AAGCACA_MIR218 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-503

Cytogenetic Map:

10q11.21

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