QuickView for RGS1 (gene)

Gene Symbol:

RGS1 Homo sapiens

Full name:

regulator of G protein signaling 1

Synonyms:

1R20, BL34, HEL-S-87, IER1, IR20, regulator of G-protein signaling 1, B-cell activation protein BL34, early response protein 1R20, epididymis secretory protein Li 87, immediate-early response 1, B-cell specific, regulator of G-protein signalling 1

Genomic Location:

Chr 1: 190811480-190815782

Description:

This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase...

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This gene encodes a member of the regulator of G-protein signalling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NKX25_01 ,  TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  TCANNTGAY_SREBP1_01 ,  AML_Q6 ,  YTATTTTNR_MEF2_02 ,  XBP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  GTACTGT_MIR101 ,  ACTGTGA_MIR27A_MIR27B ,  AML1_01 ,  TATAAA_TATA_01 ,  RGAANNTTC_HSF1_01 ,  RACCACAR_AML_Q6 ,  AML1_Q6 ,  PIT1_Q6 ,  GATA4_Q3 ,  GATA1_05 ,  TATA_01 ,  CDC5_01 ,  COREBINDINGFACTOR_Q6 ,  HTF_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-27

Cytogenetic Map:

1q31.2

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