QuickView for RHOG (gene)

Gene Symbol:

RHOG Homo sapiens

Full name:

ras homolog family member G

Synonyms:

ARHG, rho-related GTP-binding protein RhoG, ras homolog gene family, member G (rho G)

Genomic Location:

Chr 11: 3804784-3818789

Description:

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translo...

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This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  MAZ_Q6 ,  SREBP1_02 ,  TGANNYRGCA_TCF11MAFG_01 ,  ZF5_01 ,  PEA3_Q6 ,  SREBP1_Q6 ,  STAT1_03 ,  TGACCTY_ERR1_Q2 ,  AML1_01 ,  GGGAGGRR_MAZ_Q6 ,  NFE2_01 ,  LFA1_Q6 ,  CAGCTTT_MIR320 ,  AP4_01 ,  SP1_Q4_01 ,  EVI1_02 ,  EGR_Q6 ,  SP3_Q3 ,  EVI1_05 ,  TGCCTTA_MIR124A ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  CCCNNGGGAR_OLF1_01 ,  SP1_Q6 ,  RACCACAR_AML_Q6 ,  GTGCCTT_MIR506 ,  AML1_Q6 ,  AP2REP_01 ,  GATA4_Q3 ,  NFKB_Q6_01 ,  SMAD_Q6 ,  SP1_Q6_01 ,  COREBINDINGFACTOR_Q6 ,  NFKB_C ,  CP2_01 ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u

miRNA binding sites
(Source: miRecords):

hsa-miR-124 Targeted Genes

Cytogenetic Map:

11p15.4

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