QuickView for RIMS2;jsessionid=4D9EF5A5CB76A48702A9395011A7DC07 (gene)

Gene Symbol:

RIMS2 Homo sapiens

Full name:

regulating synaptic membrane exocytosis 2

Synonyms:

OBOE, RAB3IP3, RIM2, regulating synaptic membrane exocytosis protein 2, RAB3 interacting protein 3, Rab3-interacting protein, non-small cell lung cancer RimL3a protein, non-small cell lung cancer RimL3c protein, nuclear protein, rab-3-interacting molecule 2, rab-3-interacting protein 3, rab3-interacting molecule 2

Genomic Location:

Chr 8: 104582152-105334627

Description:

The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exo...

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The protein encoded by this gene is a presynaptic protein that interacts with RAB3, a protein important for normal neurotransmitter release. The encoded protein can also bind several other synaptic proteins, including UNC-13 homolog B, ELKS/Rab6-interacting/CAST family member 1, and synaptotagmin 1. This protein is involved in synaptic membrane exocytosis. Polymorphisms in this gene have been associated with degenerative lumbar scoliosis.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  IRF1_01 ,  PBX1_02 ,  MYOD_01 ,  AAGCCAT_MIR135A_MIR135B ,  RYTTCCTG_ETS2_B ,  YTATTTTNR_MEF2_02 ,  YGACNNYACAR_UNKNOWN ,  NFKAPPAB_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TGACCTY_ERR1_Q2 ,  OCT1_Q6 ,  RGAANNTTC_HSF1_01 ,  MEF2_01 ,  RP58_01 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  HSF1_01 ,  TTCYRGAA_UNKNOWN ,  E47_02 ,  GR_Q6 ,  MYOD_Q6 ,  ACCAAAG_MIR9 ,  OCT1_03 ,  NKX61_01 ,  CTTTAAR_UNKNOWN ,  HSF2_01 ,  AR_Q2 ,  CART1_01 ,  CREL_01 ,  TGATTTRY_GFI1_01 ,  GRE_C ,  MMEF2_Q6 ,  CTAGGAA_MIR384 ,  AGGAAGC_MIR5163P ,  IRF2_01 ,  TCF11MAFG_01 ,  TCF11_01 ,  MEF2_Q6_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-188 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

8q22.3

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