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QuickView for RIPK1;jsessionid=6D3E08C58BAFEDA659A1F338CEF9EC38 (gene)


Gene Symbol:
RIPK1 Homo sapiens Homo sapiens
Full name:
receptor interacting serine/threonine kinase 1
Synonyms:
RIP, RIP-1, RIP1, receptor-interacting serine/threonine-protein kinase 1, cell death protein RIP, receptor (TNFRSF)-interacting serine-threonine kinase 1, receptor-interacting protein 1, receptor-interacting protein kinase 1, serine/threonine-protein kinase RIP
Genomic Location:
Chr 6: 3022057-3060420
Description:
This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disr...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 6
6p25.2





GO Molecular Function

enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | cytokine receptor binding | protein serine/threonine kinase activity | catalytic activity | protein domain specific binding | ATP binding | ubiquitin-like protein ligase binding | anion binding | adenyl nucleotide binding | death receptor binding | MAP kinase kinase kinase activity | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | JUN kinase kinase kinase activity | purine ribonucleoside triphosphate binding | protein binding | death domain binding | ubiquitin protein ligase binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | tumor necrosis factor receptor superfamily binding | heterocyclic compound binding | small molecule binding

GO Biological Process

positive regulation of immune response | protein modification by small protein removal | regulation of JUN kinase activity | protein homooligomerization | regulation of hydrogen peroxide-induced cell death | regulation of extrinsic apoptotic signaling pathway in absence of ligand | positive regulation of macromolecule biosynthetic process | regulation of cysteine-type endopeptidase activity | response to cytokine | regulation of cellular response to oxidative stress | regulation of response to oxidative stress | immune response-regulating signaling pathway | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of localization | positive regulation of DNA-binding transcription factor activity | regulation of programmed cell death | peptidyl-amino acid modification | necroptotic process | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | regulation of MAP kinase activity | cellular response to tumor necrosis factor | positive regulation of phosphate metabolic process | necroptotic signaling pathway | innate immune response-activating signal transduction | regulation of necroptotic process | positive regulation of cellular biosynthetic process | cellular process | toll-like receptor signaling pathway | regulation of necrotic cell death | organic substance catabolic process | extrinsic apoptotic signaling pathway | negative regulation of signaling | positive regulation of reactive oxygen species metabolic process | programmed necrotic cell death | ripoptosome assembly | positive regulation of protein kinase activity | regulation of response to cytokine stimulus | negative regulation of apoptotic process | positive regulation of necrotic cell death | regulation of proteolysis | response to growth factor | positive regulation of catalytic activity | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of apoptotic signaling pathway | positive regulation of interleukin-8 production | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of stress-activated MAPK cascade | catabolic process | positive regulation of cellular protein metabolic process | cellular component organization | protein deubiquitination | MAPK cascade | positive regulation of tumor necrosis factor production | positive regulation of stress-activated protein kinase signaling cascade | response to stimulus | JNK cascade | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | signal transduction by protein phosphorylation | response to stress | regulation of response to drug | positive regulation of cysteine-type endopeptidase activity | protein serine/threonine kinase activity | programmed cell death | supramolecular fiber organization | activation of innate immune response | cellular protein catabolic process | positive regulation of proteolysis | immune response-activating signal transduction | positive regulation of protein serine/threonine kinase activity | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | positive regulation of response to oxidative stress | macromolecule modification | activation of protein kinase activity | stress-activated protein kinase signaling cascade | positive regulation of macrophage differentiation | regulation of nucleic acid-templated transcription | regulation of cellular response to stress | apoptotic process | nitrogen compound metabolic process | regulation of signal transduction | pattern recognition receptor signaling pathway | positive regulation of necroptotic process | regulation of peptidase activity | regulation of MAPK cascade | phosphorus metabolic process | protein complex oligomerization | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | amyloid fibril formation | regulation of gene expression | regulation of extrinsic apoptotic signaling pathway | cellular response to stress | protein catabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | positive regulation of cellular response to oxidative stress | MAP kinase kinase kinase activity | protein autophosphorylation | regulation of nitrogen compound metabolic process | positive regulation of JNK cascade | regulation of cysteine-type endopeptidase activity involved in apoptotic process | cytokine-mediated signaling pathway | positive regulation of intracellular signal transduction | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell differentiation | positive regulation of myeloid cell differentiation | negative regulation of extrinsic apoptotic signaling pathway | T cell apoptotic process | cellular response to cytokine stimulus | stress-activated MAPK cascade | regulation of cellular protein metabolic process | TRIF-dependent toll-like receptor signaling pathway | phosphorylation | positive regulation of endopeptidase activity | regulation of apoptotic signaling pathway | protein phosphorylation | regulation of tumor necrosis factor production | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | phosphate-containing compound metabolic process | regulation of cellular response to drug | death-inducing signaling complex assembly | positive regulation of extrinsic apoptotic signaling pathway | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | JUN kinase kinase kinase activity | positive regulation of response to drug | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | regulation of tumor necrosis factor-mediated signaling pathway | activation of MAPKK activity | activation of JNKK activity | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | positive regulation of oxidative stress-induced cell death | regulation of RNA metabolic process | viral process | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors | positive regulation of hydrogen peroxide-induced cell death | apoptotic signaling pathway | positive regulation of molecular function | activation of MAPK activity | protein-containing complex assembly | activation of immune response | protein metabolic process | positive regulation of protein modification process | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | MyD88-independent toll-like receptor signaling pathway | regulation of kinase activity | regulation of response to reactive oxygen species | regulation of DNA-binding transcription factor activity | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | cellular macromolecule catabolic process | peptidyl-serine autophosphorylation | cell surface receptor signaling pathway | metabolic process | negative regulation of I-kappaB kinase/NF-kappaB signaling | activation of cysteine-type endopeptidase activity involved in apoptotic process | regulation of RNA biosynthetic process | negative regulation of programmed cell death | positive regulation of cell death | protein kinase activity | organic substance metabolic process | cell death | positive regulation of NF-kappaB transcription factor activity | positive regulation of programmed cell death | positive regulation of kinase activity | tumor necrosis factor-mediated signaling pathway | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | regulation of ion transmembrane transport | positive regulation of cytokine production | regulation of JNK cascade | positive regulation of MAPK cascade | toll-like receptor 3 signaling pathway | positive regulation of cellular response to drug | organonitrogen compound catabolic process | regulation of stress-activated MAPK cascade | regulation of cell communication | regulation of macrophage differentiation | negative regulation of signal transduction | regulation of extrinsic apoptotic signaling pathway via death domain receptors | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | regulation of transcription, DNA-templated | I-kappaB kinase/NF-kappaB signaling | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cytokine production | protein heterooligomerization | regulation of ATP:ADP antiporter activity | regulation of endopeptidase activity | positive regulation of MAP kinase activity | regulation of developmental process | regulation of ion transport | kinase activity | peptidyl-serine phosphorylation | cellular protein modification process | regulation of transport | positive regulation of transcription, DNA-templated | regulation of reactive oxygen species metabolic process | necrotic cell death | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | regulation of anion transport | positive regulation of JUN kinase activity | positive regulation of metabolic process | positive regulation of myeloid leukocyte differentiation | immune system process | cellular metabolic process | response to tumor necrosis factor | cellular response to organic substance | regulation of cell death | activation of JUN kinase activity | negative regulation of cell death | regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of apoptotic signaling pathway | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | cellular response to growth factor stimulus | macromolecule metabolic process | regulation of phosphorus metabolic process

GO Cellular Component

ripoptosome | intracellular membrane-bounded organelle | catalytic complex | organelle membrane | cytoplasmic vesicle | cell | plasma membrane protein complex | cytoplasm | death-inducing signaling complex | intracellular organelle | receptor complex | membrane microdomain | endosome membrane | protein-containing complex | endomembrane system | plasma membrane | membrane raft | vesicle | mitochondrion | endosome | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular vesicle | intracellular | membrane