QuickView for RNF139;jsessionid=5AF227365818A7BACC2E502D0A8408D7 (gene)

Gene Symbol:

RNF139 Homo sapiens

Full name:

ring finger protein 139

Synonyms:

HRCA1, RCA1, TRC8, E3 ubiquitin-protein ligase RNF139, RING-type E3 ubiquitin transferase RNF139, multiple membrane spanning receptor TRC8, patched related protein translocated in renal cancer, translocation in renal carcinoma on chromosome 8 protein

Genomic Location:

Chr 8: 125556189-125570040

Description:

The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies o...

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The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTACTGT_MIR199A ,  TTCCGTT_MIR191 ,  AATGGAG_MIR136 ,  TGACCTY_ERR1_Q2 ,  ACTGTGA_MIR27A_MIR27B ,  RFX1_02 ,  ATACCTC_MIR202 ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  TGCCAAR_NF1_Q6 ,  COUP_DR1_Q6 ,  ERR1_Q2 ,  TGACCTTG_SF1_Q6 ,  GTTRYCATRR_UNKNOWN ,  AAGCACA_MIR218

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-128 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-191 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-27 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-96 ,  Predicted Gene Targets for miR-182 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-409-5p ,  Predicted Gene Targets for miR-505

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Cytogenetic Map:

8q24.13

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