QuickView for RNF4;jsessionid=546F649770729EDEECC87F580F6DE192 (gene)
- Gene Symbol:
- RNF4
Homo sapiens - Full name:
- ring finger protein 4
- Synonyms:
- RES4-26, SLX5, SNURF, E3 ubiquitin-protein ligase RNF4, E3 ubiquitin ligase RNF4, RING-type E3 ubiquitin transferase RNF4, small nuclear RING finger protein
- Genomic Location:
- Chr 4: 2440605-2487382
- Description:
-
The protein encoded by this gene contains a RING finger motif and acts as a transcription regulator. This protein has been shown to interact with, and inhibit the activity of, TRPS1, a transcription suppressor of GATA-mediated transcription. Transcription repressor ZNF278/PATZ is found to interact with this protein, and thus reduce the enhancement ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Gallus gallus , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-146 , Predicted Gene Targets for miR-194 , Predicted Gene Targets for miR-20 , Predicted Gene Targets for miR-205 , Predicted Gene Targets for miR-221 , Predicted Gene Targets for miR-223 , Predicted Gene Targets for miR-25 , Predicted Gene Targets for miR-34 , Predicted Gene Targets for miR-34b , Predicted Gene Targets for miR-137
- Cytogenetic Map:
-
4p16.3
GO Molecular Function
SUMO polymer binding | cation binding | hormone receptor binding | nucleosome binding | nucleic acid binding | protein-containing complex binding | signaling receptor binding | catalytic activity | chromatin binding | ubiquitin-like protein transferase activity | androgen receptor binding | DNA binding | identical protein binding | ubiquitin protein ligase activity | nuclear hormone receptor binding | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | transcription coactivator activity | protein binding | zinc ion binding | DNA-binding transcription factor activity | transcription factor binding | ubiquitin-protein transferase activity | transferase activity | transition metal ion binding | SUMO binding | ubiquitin-like protein ligase activity | steroid hormone receptor binding | transcription coregulator activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | proteolysis | response to hormone | androgen receptor signaling pathway | regulation of kinetochore assembly | regulation of organelle organization | hormone-mediated signaling pathway | positive regulation of cellular biosynthetic process | cellular process | protein K63-linked ubiquitination | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of cellular process | cellular response to lipid | regulation of metabolic process | catabolic process | regulation of protein complex assembly | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | cellular nitrogen compound biosynthetic process | regulation of centromere complex assembly | cellular protein catabolic process | cellular nitrogen compound metabolic process | proteasomal protein catabolic process | cellular response to organic cyclic compound | positive regulation of RNA biosynthetic process | protein modification process | steroid hormone mediated signaling pathway | cellular biosynthetic process | macromolecule modification | protein K6-linked ubiquitination | regulation of nucleic acid-templated transcription | cellular response to hormone stimulus | nitrogen compound metabolic process | regulation of gene expression | response to lipid | protein catabolic process | regulation of spindle assembly | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | ubiquitin protein ligase activity | biosynthetic process | aromatic compound biosynthetic process | cell communication | regulation of cellular metabolic process | transcription coactivator activity | regulation of RNA metabolic process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of microtubule-based process | protein polyubiquitination | protein metabolic process | DNA-binding transcription factor activity | response to organic substance | protein ubiquitination | cellular macromolecule catabolic process | protein autoubiquitination | metabolic process | ubiquitin-protein transferase activity | regulation of RNA biosynthetic process | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | protein modification by small protein conjugation or removal | regulation of chromosome organization | cellular response to steroid hormone stimulus | transcription, DNA-templated | intracellular receptor signaling pathway | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | protein K11-linked ubiquitination | response to arsenic-containing substance | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | cellular protein metabolic process | cellular macromolecule biosynthetic process | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | protein K48-linked ubiquitination | positive regulation of metabolic process | cellular metabolic process | cellular response to organic substance | response to steroid hormone | modification-dependent protein catabolic process | regulation of organelle assembly | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | signal transduction | positive regulation of gene expression | macromolecule metabolic process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nuclear body | PML body | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
