QuickView for RNase A (gene)

Gene Symbol:

RNASE1 Homo sapiens

Full name:

ribonuclease A family member 1, pancreatic

Synonyms:

RAC1, RIB1, RNS1, ribonuclease pancreatic, HP-RNase, RIB-1, RNase 1, RNase A, RNase upI-1, ribonuclease 1, ribonuclease A C1, ribonuclease, RNase A family, 1 (pancreatic)

Genomic Location:

Chr 14: 20339355-20340876

Description:

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is...

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This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  D. melanogaster

External Links:

Entrez Gene

Cytogenetic Map:

14q11.2

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