QuickView for ROCK1;jsessionid=B96A9EF7831E2E1D823E729431B49C39 (gene)

Gene Symbol:

ROCK1 Homo sapiens

Full name:

Rho associated coiled-coil containing protein kinase 1

Synonyms:

P160ROCK, ROCK-I, rho-associated protein kinase 1, p160 ROCK-1, renal carcinoma antigen NY-REN-35

Genomic Location:

Chr 18: 16783699-16945810

Description:

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. ...

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This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

IRF1_01 ,  CMYB_01 ,  PAX4_04 ,  MAZR_01 ,  DR3_Q4 ,  HEN1_01 ,  GCANCTGNY_MYOD_Q6 ,  VDR_Q6 ,  LYF1_01 ,  AP2GAMMA_01 ,  GGGAGGRR_MAZ_Q6 ,  STAT_Q6 ,  CAGGTG_E12_Q6 ,  AREB6_03 ,  TTGTTT_FOXO4_01 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  SMAD_Q6 ,  ETS1_B ,  IRF2_01 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

18q11.1

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