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QuickView for ROCK1 (gene)


Gene Symbol:
ROCK1 Homo sapiens Homo sapiens
Full name:
Rho associated coiled-coil containing protein kinase 1
Synonyms:
P160ROCK, ROCK-I, rho-associated protein kinase 1, p160 ROCK-1, renal carcinoma antigen NY-REN-35
Genomic Location:
Chr 18: 16783699-16945810
Description:
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
Cytogenetic Map:
chr 18
18q11.1





GO Molecular Function

GTPase binding | Rho GTPase binding | cation binding | enzyme binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | protein serine/threonine kinase activity | Ras GTPase binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | small GTPase binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | GTP-Rho binding | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

negative regulation of amyloid-beta formation | regulation of supramolecular fiber organization | negative regulation of membrane protein ectodomain proteolysis | cell morphogenesis | regulation of muscle system process | apical constriction | regulation of dephosphorylation | actin filament-based process | exocytosis | myoblast migration | positive regulation of cellular component organization | cell motility | regulation of neurogenesis | neuron projection morphogenesis | neutrophil activation | positive regulation of adherens junction organization | protein localization to cell periphery | regulation of cellular localization | intracellular signal transduction | regulation of cell development | regulation of localization | neuron projection arborization | regulation of programmed cell death | actin cytoskeleton organization | establishment of localization | regulation of autophagy | response to hormone | negative regulation of neuron death | negative regulation of cellular process | regulation of phosphatase activity | cell differentiation | nervous system development | regulation of angiotensin-activated signaling pathway | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | generation of neurons | negative regulation of proteolysis | regulation of neuron death | cellular process | secretion | leukocyte degranulation | regulation of cell motility | localization | cell projection morphogenesis | neuron development | macromolecule localization | negative regulation of apoptotic process | regulation of proteolysis | membrane docking | response to growth factor | positive regulation of nitrogen compound metabolic process | regulation of myosin-light-chain-phosphatase activity | negative regulation of cellular metabolic process | response to peptide hormone | tissue development | regulation of binding | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | actin filament-based movement | regulation of angiogenesis | regulation of cellular process | leukocyte activation | regulation of apoptotic process | leukocyte tethering or rolling | regulation of metabolic process | regulation of bicellular tight junction assembly | cortical actin cytoskeleton organization | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | negative regulation of phosphatase activity | epithelium development | smooth muscle contraction | ephrin receptor signaling pathway | cellular component organization | actin-mediated cell contraction | response to transforming growth factor beta | regulation of establishment of cell polarity | negative regulation of biomineral tissue development | muscle contraction | regulation of vasculature development | response to stimulus | neutrophil degranulation | positive regulation of protein metabolic process | leukocyte activation involved in immune response | negative regulation of angiogenesis | response to peptide | epithelial cell development | regulation of epithelial cell differentiation | protein serine/threonine kinase activity | programmed cell death | cellular localization | secretion by cell | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | cellular component assembly | protein modification process | regulation of cell adhesion | macromolecule modification | negative regulation of amyloid precursor protein catabolic process | epithelial cell morphogenesis | positive regulation of cell-matrix adhesion | regulation of establishment or maintenance of cell polarity | leukocyte migration | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | apoptotic process | positive regulation of cell junction assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | negative regulation of phosphate metabolic process | regulation of adherens junction organization | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | cell migration | regulation of MAPK cascade | phosphorus metabolic process | regulation of actin filament organization | leukocyte mediated immunity | regulation of catalytic activity | regulation of actomyosin structure organization | regulation of phosphorylation | protein localization to plasma membrane | regulation of neuron differentiation | regulation of gene expression | protein localization to membrane | regulation of epidermis development | cell projection assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of keratinocyte differentiation | regulation of nitrogen compound metabolic process | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of cellular component movement | negative regulation of binding | regulation of cellular protein metabolic process | phosphorylation | regulated exocytosis | positive regulation of amyloid-beta clearance | regulation of synaptic vesicle endocytosis | protein phosphorylation | regulation of amyloid precursor protein catabolic process | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | negative regulation of protein dephosphorylation | cell communication | negative regulation of protein binding | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of establishment of endothelial barrier | cell activation involved in immune response | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | regulation of protein phosphorylation | regulation of locomotion | response to angiotensin | neuron differentiation | negative regulation of bicellular tight junction assembly | protein metabolic process | muscle cell migration | regulation of cardiac muscle hypertrophy | positive regulation of focal adhesion assembly | positive regulation of protein modification process | response to organic substance | leukocyte adhesion to vascular endothelial cell | Rho protein signal transduction | regulation of protein dephosphorylation | regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | cell surface receptor signaling pathway | positive regulation of connective tissue replacement | leukocyte cell-cell adhesion | cell projection organization | metabolic process | regulation of protein catabolic process | negative regulation of programmed cell death | cellular protein localization | regulation of amyloid-beta clearance | regulation of tissue remodeling | regulation of vesicle-mediated transport | cell adhesion | immune response | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | negative regulation of myosin-light-chain-phosphatase activity | membrane to membrane docking | positive regulation of cell-substrate adhesion | negative regulation of cellular protein metabolic process | regulation of phosphate metabolic process | cytoskeleton organization | positive regulation of autophagy | cell-cell adhesion | cell activation | positive regulation of MAPK cascade | regulation of stress fiber assembly | negative regulation of protein catabolic process | negative regulation of protein metabolic process | regulation of cell communication | negative regulation of molecular function | signaling | regulation of protein binding | regulation of amyloid-beta formation | cell development | regulation of endocytosis | I-kappaB kinase/NF-kappaB signaling | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | negative regulation of phosphoprotein phosphatase activity | anatomical structure morphogenesis | cellular macromolecule localization | regulation of actin filament bundle assembly | positive regulation of tissue remodeling | regulation of synaptic vesicle recycling | bleb assembly | regulation of nervous system development | regulation of developmental process | regulation of G-protein coupled receptor protein signaling pathway | regulation of phosphoprotein phosphatase activity | kinase activity | developmental process | organelle organization | cellular protein modification process | cortical cytoskeleton organization | cellular extravasation | vascular endothelial growth factor receptor signaling pathway | regulation of cell junction assembly | regulation of transport | negative regulation of vasculature development | Ras protein signal transduction | regulation of endothelial cell differentiation | neutrophil mediated immunity | response to organonitrogen compound | negative regulation of dephosphorylation | epithelial cell differentiation | negative regulation of hydrolase activity | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | immune system process | cellular metabolic process | regulation of cell death | negative regulation of cell death | regulation of cellular component organization | regulation of epidermal cell differentiation | regulation of cytoskeleton organization | muscle system process | positive regulation of signaling | signal transduction | regulation of signaling | positive regulation of gene expression | regulation of cell-matrix adhesion | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process

GO Cellular Component

secretory granule | bleb | centriole | intracellular membrane-bounded organelle | ruffle | organelle membrane | microtubule organizing center | cytoplasmic stress granule | cytoplasmic vesicle | cell | ribonucleoprotein granule | lamellipodium | cytoplasmic vesicle lumen | cytoplasm | intracellular organelle | Golgi apparatus | protein-containing complex | cell projection | secretory vesicle | endomembrane system | plasma membrane | cell leading edge | ribonucleoprotein complex | vesicle | microtubule cytoskeleton | Golgi membrane | extracellular region | membrane-bounded organelle | organelle | cytoplasmic ribonucleoprotein granule | cell periphery | membrane-enclosed lumen | secretory granule lumen | amyloid-beta complex | cytosol | intracellular vesicle | cytoskeleton | intracellular | membrane | vesicle lumen