QuickView for RORA;jsessionid=87B0FB3C37361706AF7BA5CD089E511C (gene)

Gene Symbol:

RORA Homo sapiens

Full name:

RAR related orphan receptor A

Synonyms:

NR1F1, ROR1, ROR2, ROR3, RZR-ALPHA, RZRA, nuclear receptor ROR-alpha, ROR-alpha, nuclear receptor RZR-alpha, nuclear receptor subfamily 1 group F member 1, retinoic acid receptor-related orphan receptor alpha, retinoid-related orphan receptor alpha, thyroid hormone nuclear receptor alpha variant 4, transcription factor RZR-alpha

Genomic Location:

Chr 15: 58576755-59308794

Description:

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogene...

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The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  POU6F1_01 ,  RTAAACA_FREAC2_01 ,  PU1_Q6 ,  MYOD_01 ,  GATA1_01 ,  ZIC1_01 ,  FOXJ2_02 ,  RYTTCCTG_ETS2_B ,  FOX_Q2 ,  GATA3_01 ,  AP3_Q6 ,  TTCNRGNNNNTTC_HSF_Q6 ,  FOXD3_01 ,  AAANWWTGC_UNKNOWN ,  AREB6_04 ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  GR_Q6_01 ,  MAF_Q6 ,  GATA1_04 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  TATAAA_TATA_01 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  PAX4_02 ,  GGGYGTGNY_UNKNOWN ,  GGATTA_PITX2_Q2 ,  CEBP_01 ,  LHX3_01 ,  HNF3B_01 ,  FOXJ2_01 ,  PITX2_Q2 ,  HIF1_Q5 ,  NKX25_02 ,  RAAGNYNNCTTY_UNKNOWN ,  TGCCAAR_NF1_Q6 ,  POU1F1_Q6 ,  HFH8_01 ,  GATA1_02 ,  RNGTGGGC_UNKNOWN ,  GFI1_01 ,  HLF_01 ,  FREAC2_01 ,  CEBP_Q3 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  AP2REP_01 ,  CEBP_C ,  PIT1_Q6 ,  IK2_01 ,  WTTGKCTG_UNKNOWN ,  YTAATTAA_LHX3_01 ,  RGAGGAARY_PU1_Q6 ,  PAX5_01 ,  IK1_01 ,  SMAD4_Q6 ,  TGACAGNY_MEIS1_01 ,  CCANNAGRKGGC_UNKNOWN ,  SMAD_Q6 ,  CDC5_01 ,  ZF5_B ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  HNF1_Q6 ,  GGGTGGRR_PAX4_03

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Cytogenetic Map:

15q22.2

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