QuickView for RRM2 (gene)

Gene Symbol:

RRM2 Homo sapiens

Full name:

ribonucleotide reductase regulatory subunit M2

Synonyms:

R2, RR2, RR2M, ribonucleoside-diphosphate reductase subunit M2, ribonucleotide reductase M2 polypeptide, ribonucleotide reductase small chain, ribonucleotide reductase small subunit

Genomic Location:

Chr 2: 10180184-10188074

Description:

This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isofor...

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This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

E2F4DP1_01 ,  CATTGTYY_SOX9_B1 ,  E2F_Q6_01 ,  E2F_Q6 ,  E2F_Q4 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  E2F1DP2_01 ,  CTTTAAR_UNKNOWN ,  E2F1DP1_01 ,  GGCACTT_MIR519E ,  E2F1DP1RB_01 ,  E2F_02 ,  E2F1_Q3 ,  E2F4DP2_01 ,  E2F1_Q6 ,  SGCGSSAAA_E2F1DP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-20

Cytogenetic Map:

2p25.1

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