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QuickView for RTN4;jsessionid=CEEF0A028C9D537A47EF2A4EB245F2F2 (gene)


Gene Symbol:
RTN4 Homo sapiens Homo sapiens
Full name:
reticulon 4
Synonyms:
ASY, NI220/250, NOGO, NSP, NSP-CL, Nbla00271, Nbla10545, RTN-X, RTN4-A, RTN4-B1, RTN4-B2, RTN4-C, reticulon-4, Human NogoA, My043 protein, foocen, neurite growth inhibitor 220, neurite outgrowth inhibitor, neuroendocrine-specific protein C homolog, reticulon 5
Genomic Location:
Chr 2: 55052829-55131238
Description:
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. The product of this gene is a potent neurite outgrowth inhibitor which may also help block the regeneration of the central nervous sys...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Danio rerio Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 2
2p16.1





GO Molecular Function

cadherin binding | enzyme binding | nucleic acid binding | ubiquitin-like protein ligase binding | organic cyclic compound binding | cell adhesion molecule binding | protein binding | ubiquitin protein ligase binding | heterocyclic compound binding | RNA binding

GO Biological Process

endoplasmic reticulum tubular network membrane organization | brain development | nucleus organization | positive regulation of locomotion | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | positive regulation of axon regeneration | regulation of cell development | protein stabilization | regulation of localization | regulation of programmed cell death | negative regulation of cellular process | endoplasmic reticulum tubular network formation | positive regulation of developmental process | nuclear pore complex assembly | response to metal ion | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | epithelial to mesenchymal transition | positive regulation of axonogenesis | neurogenesis | positive regulation of cellular component movement | positive regulation of collateral sprouting | generation of neurons | membrane organization | mesenchyme development | blood vessel morphogenesis | cellular process | negative regulation of axonogenesis | regulation of cell motility | localization | heart morphogenesis | forebrain cell migration | negative regulation of axon regeneration | neuron development | negative regulation of developmental growth | endomembrane system organization | regulation of neuron projection development | response to inorganic substance | tissue development | regulation of cell differentiation | cell recognition | regulation of protein kinase B signaling | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | gliogenesis | cellular component organization | negative regulation of dendrite extension | negative regulation of cell morphogenesis involved in differentiation | endoplasmic reticulum membrane organization | cellular response to metal ion | positive regulation of epithelial cell migration | head development | response to stimulus | vasculature development | regulation of cellular protein localization | cerebral cortex radial glia guided migration | positive regulation of cellular protein localization | regulation of cell proliferation | negative regulation of neuron projection development | regulation of mammary gland epithelial cell proliferation | tube morphogenesis | telencephalon cell migration | programmed cell death | regulation of dendrite extension | positive regulation of mammary gland epithelial cell proliferation | cellular response to inorganic substance | cardiovascular system development | regulation of neuron projection regeneration | regulation of cellular component size | cellular component assembly | regulation of axon extension | regulation of morphogenesis of a branching structure | positive regulation of ERBB signaling pathway | blood vessel development | regulation of cellular response to stress | locomotion | apoptotic process | system development | positive regulation of response to wounding | regulation of signal transduction | negative regulation of growth | regulation of protein stability | positive regulation of neuron projection development | multicellular organism development | cell migration | positive regulation of protein localization to endoplasmic reticulum | regulation of axonogenesis | positive regulation of protein kinase B signaling | positive regulation of neuron projection regeneration | cardiac epithelial to mesenchymal transition | telencephalon development | negative regulation of formation of growth cone in injured axon | positive regulation of collateral sprouting of injured axon | regulation of neuron differentiation | axon development | neuron recognition | animal organ morphogenesis | regulation of cell migration | glial cell migration | positive regulation of cell projection organization | positive regulation of intracellular signal transduction | regulation of cellular component movement | axonal fasciculation | positive regulation of cell differentiation | positive regulation of cell migration | angiogenesis | cellular protein-containing complex assembly | cerebral cortex cell migration | pore complex assembly | negative regulation of response to wounding | positive regulation of signal transduction | heart development | positive regulation of cell proliferation | regulation of locomotion | neuron projection fasciculation | cerebral cortex development | negative regulation of cell growth | neuron differentiation | protein-containing complex assembly | regulation of cell morphogenesis involved in differentiation | regulation of protein localization to endoplasmic reticulum | regulation of growth | cellular response to calcium ion | negative regulation of cell projection organization | regulation of intracellular signal transduction | nuclear pore organization | anatomical structure development | positive regulation of neurogenesis | cell projection organization | positive regulation of cell development | mesenchymal cell differentiation | negative regulation of axon extension | neuron projection development | cell death | animal organ development | cerebral cortex radially oriented cell migration | forebrain development | negative regulation of neuron differentiation | pallium development | regulation of axon regeneration | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of collateral sprouting | regulation of response to wounding | regulation of cell communication | positive regulation of developmental growth | positive regulation of growth | cell development | regulation of ERBB signaling pathway | regulation of developmental growth | regulation of epithelial cell proliferation | regulation of cell size | anatomical structure morphogenesis | regulation of nervous system development | regulation of developmental process | negative regulation of neuron projection regeneration | developmental process | organelle organization | regulation of cell growth | tube development | response to calcium ion | central nervous system development | positive regulation of neuron differentiation | regulation of cell projection organization | endoplasmic reticulum tubular network organization | regulation of protein localization | regulation of cell death | positive regulation of cell motility | positive regulation of cell morphogenesis involved in differentiation | negative regulation of cell development | regulation of branching morphogenesis of a nerve | circulatory system development | endoplasmic reticulum organization | negative regulation of cell differentiation | regulation of cellular component organization | positive regulation of signaling | regulation of signaling | negative regulation of neurogenesis | positive regulation of ERBB3 signaling pathway | multicellular organismal process

GO Cellular Component

integral component of membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | somatodendritic compartment | cell body | cell | integral component of endoplasmic reticulum membrane | neuronal cell body | distal axon | dendrite terminus | intrinsic component of membrane | cytoplasm | intracellular organelle | intrinsic component of endoplasmic reticulum membrane | endoplasmic reticulum | dendritic tree | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | endomembrane system | endoplasmic reticulum membrane | postsynapse | plasma membrane | nuclear envelope | postsynaptic density | asymmetric synapse | site of polarized growth | membrane-bounded organelle | nucleus | endoplasmic reticulum tubular network membrane | organelle | postsynaptic specialization | cell periphery | axon | growth cone | endoplasmic reticulum tubular network | dendritic growth cone | intracellular | membrane