QuickView for Rab6a (gene)

Gene Symbol:

RAB6A Homo sapiens

Full name:

RAB6A, member RAS oncogene family

Synonyms:

RAB6, ras-related protein Rab-6A, RAB6, member RAS oncogene family, Rab GTPase

Genomic Location:

Chr 11: 73064331-73149849

Description:

This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes a...

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This gene encodes a member of the RAB family, which belongs to the small GTPase superfamily. GTPases of the RAB family bind to various effectors to regulate the targeting and fusion of transport carriers to acceptor compartments. This protein is located at the Golgi apparatus, which regulates trafficking in both a retrograde (from early endosomes and Golgi to the endoplasmic reticulum) and an anterograde (from the Golgi to the plasma membrane) directions. Myosin II is an effector of this protein in these processes. This protein is also involved in assembly of human cytomegalovirus (HCMV) by interacting with the cellular protein Bicaudal D1, which interacts with the HCMV virion tegument protein, pp150. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  TTTGCAG_MIR518A2 ,  CCCACAT_MIR2993P ,  NFAT_Q6 ,  TGANNYRGCA_TCF11MAFG_01 ,  GCANCTGNY_MYOD_Q6 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  TGAGATT_MIR216 ,  SRY_01 ,  CREB_Q4 ,  CREBP1_Q2 ,  AGCATTA_MIR155 ,  GCTTGAA_MIR498 ,  PAX4_02 ,  RP58_01 ,  NKX62_Q2 ,  TGCCTTA_MIR124A ,  CCAWYNNGAAR_UNKNOWN ,  ATTCTTT_MIR186 ,  GGGCGGR_SP1_Q6 ,  E4F1_Q6 ,  AHR_Q5 ,  NFY_Q6 ,  ACTGCAG_MIR173P ,  NRF2_Q4 ,  HAND1E47_01 ,  TAATTA_CHX10_01 ,  YGCGYRCGC_UNKNOWN ,  TTGTTT_FOXO4_01 ,  CEBP_C ,  CART1_01 ,  CREB_Q2 ,  TGCTTTG_MIR330 ,  CTTTGT_LEF1_Q2 ,  CACBINDINGPROTEIN_Q6 ,  GGCAGTG_MIR3243P ,  CREB_01 ,  FOXO4_02 ,  GGGTGGRR_PAX4_03 ,  AAGCACA_MIR218 ,  OLF1_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-216 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-324-3p ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-299-3p ,  Predicted Gene Targets for miR-543

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Cytogenetic Map:

11q13.4

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