cation binding | catalytic activity | ubiquitin-like protein transferase activity | ubiquitin protein ligase activity | ion binding | protein binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity | metal ion binding
proteolysis | negative regulation of cellular process | cellular process | protein K63-linked ubiquitination | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | negative regulation of signaling | regulation of cellular process | catabolic process | negative regulation of epidermal growth factor receptor signaling pathway | cellular protein catabolic process | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | protein modification process | macromolecule modification | nitrogen compound metabolic process | regulation of signal transduction | protein catabolic process | protein modification by small protein conjugation | ubiquitin protein ligase activity | protein polyubiquitination | protein metabolic process | protein ubiquitination | cellular macromolecule catabolic process | protein autoubiquitination | metabolic process | ubiquitin-protein transferase activity | negative regulation of ERBB signaling pathway | organic substance metabolic process | regulation of epidermal growth factor receptor signaling pathway | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | negative regulation of signal transduction | regulation of ERBB signaling pathway | cellular protein metabolic process | cellular protein modification process | protein K48-linked ubiquitination | cellular metabolic process | modification-dependent protein catabolic process | regulation of signaling | macromolecule metabolic process
cell | cytoplasm | cytosol | intracellular