QuickView for Rac1 (gene)
- Gene Symbol:
- RAC1
Homo sapiens - Full name:
- Rac family small GTPase 1
- Synonyms:
- MIG5, MRD48, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1, cell migration-inducing gene 5 protein, ras-like protein TC25, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)
- Genomic Location:
- Chr 7: 6380651-6410123
- Description:
-
The protein encoded by this gene is a GTPase which belongs to the RAS superfamily of small GTP-binding proteins. Members of this superfamily appear to regulate a diverse array of cellular events, including the control of cell growth, cytoskeletal reorganization, and the activation of protein kinases. Two transcript variants encoding different isofo...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , Macaca mulatta , Bos taurus , Danio rerio , Gallus gallus , Canis lupus familiaris , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan): -
Predicted Gene Targets for miR-99 , Predicted Gene Targets for miR-101 , Predicted Gene Targets for miR-142-3p , Predicted Gene Targets for miR-144 , Predicted Gene Targets for miR-194 , Predicted Gene Targets for miR-200b , Predicted Gene Targets for miR-361 , Predicted Gene Targets for miR-485-5p , Predicted Gene Targets for miR-96 , Predicted Gene Targets for miR-137
- Cytogenetic Map:
-
7p22.1
GO Molecular Function
kinase binding | guanyl ribonucleotide binding | GTPase binding | ribonucleoside binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | hydrolase activity | carbohydrate derivative binding | protein serine/threonine kinase activity | pyrophosphatase activity | Ras GTPase binding | catalytic activity | anion binding | ATPase binding | nucleoside-triphosphatase activity | purine nucleotide binding | Rho GDP-dissociation inhibitor binding | thioesterase binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | GDP-dissociation inhibitor binding | protein binding | transferase activity, transferring phosphorus-containing groups | GTP binding | phosphotransferase activity, alcohol group as acceptor | hydrolase activity, acting on acid anhydrides | protein kinase activity | transferase activity | small GTPase binding | Rab GTPase binding | nucleoside binding | purine ribonucleotide binding | kinase activity | histone deacetylase binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
positive regulation of immune response | regulation of leukocyte chemotaxis | regulation of supramolecular fiber organization | cell morphogenesis | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | actin filament-based process | exocytosis | positive regulation of Ras protein signal transduction | regulation of microtubule polymerization or depolymerization | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | neuron projection morphogenesis | immune response-regulating signaling pathway | ruffle organization | neutrophil activation | positive regulation of adherens junction organization | intracellular signal transduction | regulation of cell development | regulation of localization | cell-substrate adhesion | negative regulation of interleukin-23 production | actin cytoskeleton organization | establishment of localization | immune response-regulating cell surface receptor signaling pathway | regulation of immune system process | neuron migration | negative regulation of cellular process | positive regulation of developmental process | substrate adhesion-dependent cell spreading | positive regulation of lymphocyte activation | cell differentiation | immune response-activating cell surface receptor signaling pathway | defense response | nervous system development | lymphocyte costimulation | cell part morphogenesis | neurogenesis | bone remodeling | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of DNA replication | regulation of organelle organization | positive regulation of cellular component movement | generation of neurons | tissue homeostasis | positive regulation of cellular biosynthetic process | cellular process | secretion | positive regulation of microtubule polymerization | Fc-gamma receptor signaling pathway involved in phagocytosis | leukocyte degranulation | regulation of cell motility | localization | cell projection morphogenesis | negative regulation of receptor-mediated endocytosis | tissue remodeling | neuron development | hemostasis | regulation of chemotaxis | positive regulation of nitrogen compound metabolic process | regulation of cell differentiation | interspecies interaction between organisms | anatomical structure homeostasis | positive regulation of lamellipodium assembly | regulation of immune response | regulation of cellular process | positive regulation of lamellipodium organization | leukocyte activation | regulation of metabolic process | positive regulation of neutrophil migration | regulation of protein complex assembly | mast cell chemotaxis | small GTPase mediated signal transduction | positive regulation of cellular protein metabolic process | bone resorption | regulation of establishment of planar polarity | ephrin receptor signaling pathway | cellular component organization | regulation of neutrophil chemotaxis | response to stimulus | lamellipodium assembly | cellular response to mechanical stimulus | neutrophil degranulation | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | leukocyte activation involved in immune response | multicellular organismal homeostasis | positive regulation of actin filament bundle assembly | positive regulation of cell-cell adhesion | protein serine/threonine kinase activity | supramolecular fiber organization | positive regulation of cell activation | cellular localization | secretion by cell | ruffle assembly | actin filament polymerization | positive regulation of T cell activation | immune response-activating signal transduction | negative regulation of transport | G-protein coupled receptor signaling pathway | regulation of cellular component size | cellular component assembly | protein modification process | mast cell migration | regulation of cell adhesion | Wnt signaling pathway, planar cell polarity pathway | macromolecule modification | cell-cell signaling | cell chemotaxis | positive regulation of cell-matrix adhesion | cell surface receptor signaling pathway involved in cell-cell signaling | positive regulation of stress fiber assembly | leukocyte migration | blood coagulation | locomotion | regulation of cell projection assembly | positive regulation of cell junction assembly | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | Wnt signaling pathway | regulation of adherens junction organization | regulation of actin cytoskeleton organization | multicellular organism development | cell migration | positive regulation of DNA replication | phosphorus metabolic process | regulation of actin filament organization | actin filament organization | leukocyte mediated immunity | regulation of actomyosin structure organization | regulation of granulocyte chemotaxis | regulation of phosphorylation | wound healing | localization within membrane | Fc-gamma receptor signaling pathway | regulation of T cell activation | regulation of receptor-mediated endocytosis | regulation of small GTPase mediated signal transduction | positive regulation of chemotaxis | hepatocyte growth factor receptor signaling pathway | cell projection assembly | negative regulation of cytokine production | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | positive regulation of Rho protein signal transduction | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | actin polymerization or depolymerization | positive regulation of cell projection organization | protein polymerization | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | vesicle-mediated transport | regulation of cellular component movement | Fc-epsilon receptor signaling pathway | positive regulation of cell differentiation | non-canonical Wnt signaling pathway | positive regulation of cell migration | regulation of Rho protein signal transduction | cell proliferation | regulation of cellular protein metabolic process | phosphorylation | immune response-regulating cell surface receptor signaling pathway involved in phagocytosis | regulated exocytosis | cellular protein-containing complex assembly | regulation of interleukin-23 production | regulation of hydrogen peroxide metabolic process | protein phosphorylation | regulation of respiratory burst | cell morphogenesis involved in differentiation | regulation of leukocyte migration | phosphate-containing compound metabolic process | cell communication | regulation of cellular metabolic process | Rac protein signal transduction | positive regulation of leukocyte chemotaxis | inflammatory response | cell activation involved in immune response | positive regulation of cytoskeleton organization | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | leukocyte chemotaxis | homeostatic process | regulation of protein phosphorylation | regulation of locomotion | viral process | coagulation | regulation of microtubule-based process | neuron differentiation | lamellipodium organization | protein-containing complex assembly | activation of immune response | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of focal adhesion assembly | positive regulation of protein modification process | Rho protein signal transduction | response to wounding | response to mechanical stimulus | regulation of animal organ morphogenesis | import into cell | regulation of intracellular signal transduction | regulation of focal adhesion assembly | anatomical structure development | cell surface receptor signaling pathway | positive regulation of small GTPase mediated signal transduction | negative regulation of endocytosis | cell projection organization | metabolic process | positive regulation of cell development | regulation of defense response to virus by virus | regulation of microtubule polymerization | positive regulation of supramolecular fiber organization | regulation of neutrophil migration | positive regulation of leukocyte activation | regulation of body fluid levels | positive regulation of neutrophil chemotaxis | regulation of vesicle-mediated transport | endocytosis | cell adhesion | immune response | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | positive regulation of cell-substrate adhesion | regulation of cell activation | positive regulation of leukocyte migration | regulation of phosphate metabolic process | cytoskeleton organization | cell activation | regulation of stress fiber assembly | T cell costimulation | regulation of cell communication | signaling | cell-matrix adhesion | cell development | regulation of endocytosis | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | regulation of cytokine production | regulation of Ras protein signal transduction | anatomical structure morphogenesis | regulation of actin filament bundle assembly | positive regulation of plasma membrane bounded cell projection assembly | regulation of developmental process | positive regulation of DNA metabolic process | kinase activity | developmental process | organelle organization | Fc receptor signaling pathway | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | Fc receptor mediated stimulatory signaling pathway | regulation of cell junction assembly | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | positive regulation of protein polymerization | Ras protein signal transduction | regulation of lamellipodium assembly | neutrophil mediated immunity | positive regulation of granulocyte chemotaxis | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | regulation of actin filament-based process | regulation of cell projection organization | immune system process | cellular metabolic process | positive regulation of cell motility | regulation of substrate adhesion-dependent cell spreading | positive regulation of cell morphogenesis involved in differentiation | chemotaxis | semaphorin-plexin signaling pathway | phagocytosis | positive regulation of leukocyte cell-cell adhesion | regulation of microtubule cytoskeleton organization | positive regulation of substrate adhesion-dependent cell spreading | regulation of cellular component organization | regulation of cytoskeleton organization | positive regulation of signaling | signal transduction | regulation of signaling | regulation of cell-matrix adhesion | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | supramolecular fiber | dendritic spine | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | ruffle | somatodendritic compartment | adherens junction | organelle membrane | cell projection membrane | tertiary granule | focal adhesion | cytoplasmic vesicle | cell | ribonucleoprotein granule | ruffle membrane | lamellipodium | cytoplasm | cell-substrate junction | intracellular organelle | actin cytoskeleton | endoplasmic reticulum | dendritic tree | secretory granule membrane | ficolin-1-rich granule membrane | leading edge membrane | melanosome | endosome membrane | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | cell projection | recycling endosome | secretory vesicle | endomembrane system | neuron spine | endoplasmic reticulum membrane | postsynapse | plasma membrane | cell leading edge | ribonucleoprotein complex | vesicle | extracellular exosome | Golgi membrane | endosome | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | cytoplasmic ribonucleoprotein granule | recycling endosome membrane | vesicle membrane | extracellular space | cell periphery | trans-Golgi network | cell-substrate adherens junction | cytosol | intracellular vesicle | actin filament | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex | cytoplasmic vesicle membrane
