QuickView for Rag2 (gene)

Gene Symbol:

RAG2 Homo sapiens

Full name:

recombination activating 2

Synonyms:

RAG-2, V(D)J recombination-activating protein 2, recombination activating gene 2

Genomic Location:

Chr 11: 36570069-36576388

Description:

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating...

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This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TAL1ALPHAE47_01 ,  YTATTTTNR_MEF2_02 ,  TTF1_Q6 ,  TAL1BETAE47_01 ,  RP58_01 ,  HAND1E47_01 ,  TAL1BETAITF2_01 ,  ACAWYAAAG_UNKNOWN

Cytogenetic Map:

11p12

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