Correlation Engine 2.0
Clear Search sequence regions
Bookmark Forward

QuickView for Ranitidine (compound)

Name: Ranitidine
PubChem Compound ID: 3001055
Description: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Molecular formula: C13H22N4O3S
Molecular weight: 314.405 g/mol
Istomar; Ranitidina [INN-Spanish]; RND; Weichilin; Verlost; 1,1-Ethenediamine, N-[2-[[[5-[(dimethylamino)methyl]-2-furanyl]methyl]thio]ethyl]-N'-methyl-2-nitro-, (E)-; 1,1-Ethenediamine, N-(2-(((5-((dimethylamino)methyl)-2-furanyl)methyl)thio)ethyl)-N'-methyl-2-nitro-; Raniter; Ptinolin; NCGC00024387-02.
show more »
Name: Ranitidine
Name (isomeric): DB00863
Drug Type: small molecule
Description: A non-imidazole blocker of those histamine receptors that mediate gastric secretion (H2 receptors). It is used to treat gastrointestinal ulcers.
Rantidine HCL; Ranitidine Base; Ranitidine hydrochloride; Ranitidine HCL
Brand: Sostril, Ranicux, Zandid, Gastrolav, Ranitidina Tamarang, Gastridina, Ranibloc, Ulcolind Rani, Serviradine, Renatac, Raniplex, Coralen, Zantarac, Ranitidin Basics, Raniberta, Rani AbZ, Ranimerck, Ranic, Rani-BASF, Ranitidin NM, Noktome, Ranitic, RAN, Digestosan, Tanidina, Ranigen, Raniogas, Ranilonga, Ranitin, Rani-Puren, Rani-Q, Ranifur, Ranidine, Noctone, Ranitidin Heumann, Ergan, Ranitidina predilu Grif, Ranitidin Dyna, Rani 2, Esofex, Ulcodin, Viserul, Novo-Radinine, Ranitidin Arcana, Regalil, Zantac In Plastic Container, Zantac 75, Ranitidin Helvepharm, Ranitidin-Isis, Ranitab, Nu-Ranit, Ran H2, Santanol, Ran Lich, Neugal, Gastrosedol, Ranuber, Raniberl, Ranidil, Rantacid, Ranidin, Ranitidin, Ranitidin Hexal, Label, Rani-nerton, Ranitidin PB, Pep-Rani, Ranitidin Millet, Ranitidin von ct, Ulcecur, Toriol, Ptinolin, Terposen, Ranitidin Normon, Taural, Ranitidin 1A Pharma, Mideran, Ultidine, Lake, Ranitidin Duncan, Ulcex, Rozon, Ranitidin-Cophar, Ulcirex, Apo-Ranitidin, Ranitidin AL, Ranisan, Ranitidin AWD, Kuracid, Quadrin, Ranitidin Merck, Melfax, Ranobel, Ulsaven, Ranitidin Atid, Fendibina, Rani-Sanorania, Gastrial, Logat, Trigger, Normon, Ranidura, Radin, Alter-H2, Ranigasan, Ranitine, Zantac 150, Zantac, Quantor, Ranigast, Artomil, Alvidina, Ranitiget, Raniben, Ranitidin-ratiopharm, Azuranit, Ranitidin Stada, Rubiulcer, Microtid, Alquen, Zantic, Raticina
Brand name mixture: Tritec(ranitidine bismuth citrate salt)
Category: Anti-Ulcer Agents, Histamine H2 Antagonists
CAS number: 66357-35-5
Indication: Used in the treatment of peptic ulcer disease (PUD), dyspepsia, stress ulcer prophylaxis, and gastroesophageal reflux disease (GERD).
Ranitidine is a histamine H2-receptor antagonist similar to cimetidine and famotidine. An H2-receptor antagonist, often shortened to H2 antagonist, is a drug used to block the action of histamine on parietal cells in the stomach, decreasing acid production by these cells. These drugs are used in the treatment of dyspepsia, however their use has wan...
show more »
Mechanism of Action:
The H2 antagonists are competitive inhibitors of histamine at the parietal cell H2 receptor. They suppress the normal secretion of acid by parietal cells and the meal-stimulated secretion of acid. They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from binding on parietal cell H2 receptors which stimul...
show more »
Absorption: Approximately 50% bioavailability orally.
Protein binding: 15%
Biotransformation: Hepatic. Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites, accounting for approximately 4%, 1%, and 1% of the dose, respectively.
Route of elimination: The principal route of excretion is the urine (active tubular excretion, renal clearance 410mL/min), with approximately 30% of the orally administered dose collected in the urine as unchanged drug in 24 hours.
Half Life: 2.8-3.1 hours
Clearance: 29 mL/min [clinically significant renal function impairment] 3 mL/min/Kg [neonatal patients]
Toxicity: LD50=77mg/kg (orally in mice). Symptoms of overdose include muscular tremors, vomiting, and rapid respiration.
Affected organisms: Humans and other mammals
Food interaction:
Avoid alcohol.
Avoid milk, calcium containing dairy products, iron, antacids, or aluminum salts 2 hours before or 6 hours after using antacids while on this medication.
Take without regard to meals.
Avoid excessive quantities of coffee or tea (Caffeine).
Drug interaction:
DasatinibRanitidine may decrease the serum level of dasatinib.
AnisindioneRanitidine may increase the anticoagulant effect of anisindione. (Conflicting evidence)
WarfarinRanitidine may increase the anticoagulant effect of warfarin. (Conflicting evidence)
TolazolineAnticipated loss of efficacy of tolazoline
ItraconazoleThe H2-receptor antagonist, ranitidine, may decrease the absorption of itraconazole.
show more »