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QuickView for Remifentanil (compound)
PubChem
| Name: | remifentanil |
|---|---|
| PubChem Compound ID: | 60814 |
| Molecular formula: | C20H29ClN2O5 |
| Molecular weight: | 412.907 g/mol |
| Synonyms: |
1-Piperidinepropanoic acid, 4-(methoxycarbonyl)-4-((1-oxopropyl)phenylamino)-, methyl ester, monohydrochloride; Ultiva; Ultiva (TN); GI-87084B; 4-Carboxy-4-(N-phenylpropionamido)-1-piperidine propionic acid, dimethyl ester, monohydrochloride; GI 87084B; 132539-07-2; D01177; Remifentanil hydrochloride; Remifentanil hydrochloride [USAN].
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DrugBank
Identification
| Name: | remifentanil |
|---|---|
| Name (isomeric): | DB00899 |
| Drug Type: | small molecule |
| Synonyms: |
Remifentanyl
|
| Brand: | Ultiva |
| Category: | Anesthetics, Intravenous, Hypnotics and Sedatives, Analgesics, Opioid |
| CAS number: | 132875-61-7 |
Pharmacology
| Indication: | For use during the induction and maintenance of general anesthesia. |
|---|---|
| Pharmacology: |
Remifentanil is an opioid agonist with rapid onset and peak effect and ultra-short duration of action. The opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. The analgesic effects of remifentanil are rapid in onset and offset. Its effects and side effects are dose dependent and similar to other opioids. Remifenta...
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| Mechanism of Action: | Remifentanil is a µ-opioid agonist with rapid onset and peak effect, and short duration of action. The µ-opioid activity of remifentanil is antagonized by opioid antagonists such as naloxone. |
| Protein binding: | 70% (bound to plasma proteins) |
| Biotransformation: | By hydrolysis of the propanoic acid-methyl ester linkage by nonspecific blood and tissue esterases. |
| Route of elimination: | Remifentanil is an esterase-metabolized opioid. The carboxylic acid metabolite is essentially inactive (1/4600 as potent as remifentanil in dogs) and is excreted by the kidneys with an elimination half-life of approximately 90 minutes. |
| Half Life: | 1-20 minutes |
| Clearance: | 40 mL/min/kg [young, healthy adults] |
| Affected organisms: | Humans and other mammals |
Interactions
| Drug interaction: |
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Targets
