Name: | Reserpine |
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PubChem Compound ID: | 11039341 |
Description: | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. |
Molecular formula: | C33H40N2O9 |
Molecular weight: | 608.679 g/mol |
Name: | Reserpine |
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Name (isomeric): | DB00206 |
Drug Type: | small molecule |
Description: | An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use. |
Brand: | Salutensin-Demi, Serpivite, Diupres-250, Sandril, Regroton, Diupres-500, Unipres, Serpasil-Apresoline, Hydromox R, Reserfia, Serpasil-Esidrix #1, Serpasil-Esidrix #2, Rau-Sed, Metatensin #4, Salutensin, Serpasil, Hydroserpine Plus (R-H-H), Hydrap-ES, Serpalan, Hiserpia, Serpate, Naquival, Dralserp, Novoreserpine, Metatensin #2, Ser-A-Gen, Serpanray, Cam-Ap-Es, Renese-R, Diutensen-R, Demi-Regroton |
Brand name mixture: | Hydropres 50 Tab(Hydrochlorothiazide + Reserpine), SER-AP-ES Tab(Hydralazine Hydrochloride + Hydrochlorothiazide + Reserpine), Hydropres 25 Tab(Hydrochlorothiazide + Reserpine) |
Category: | Peripheral Adrenergic Inhibitors, Adrenergic Uptake Inhibitors, Antipsychotic Agents, Antipsychotics, Antihypertensive Agents |
CAS number: | 50-55-5 |
Indication: | Foe the treatment of hypertension |
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Pharmacology: |
Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, for...
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Mechanism of Action: |
Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catechola...
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Protein binding: | 62% |
Route of elimination: | Reserpine is extensively metabolized to inactive compounds. It is slowly excreted via the urine and feces. |
Toxicity: | Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg/kg; IPR-RAT LD50 44 mg/kg; IVN-RAT LD50 15 mg/kg; ORL-MUS LD50 200 mg/kg; SCU-MUS LD50 52 mg/kg; IPR-RBT LD50 7 mg/kg |
Affected organisms: | Humans and other mammals |
Food interaction: |
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