QuickView for RhoA (gene)
- Gene Symbol:
- RHOA
Homo sapiens - Full name:
- ras homolog family member A
- Synonyms:
- ARH12, ARHA, RHO12, RHOH12, transforming protein RhoA, Aplysia ras-related homolog 12, oncogene RHO H12, small GTP binding protein RhoA
- Genomic Location:
- Chr 3: 49371582-49424530
- Description:
-
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associat...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Bos taurus , Gallus gallus , Canis lupus familiaris , Pan troglodytes , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
3p21.31
| Transcripts Names |
|---|
| NM_001664 |
| NM_001313944 |
| NM_001313943 |
| NM_001313945 |
| NM_001313941 |
| NM_001313947 |
| NM_001313946 |
GO Molecular Function
kinase binding | GDP binding | guanyl ribonucleotide binding | ribonucleoside binding | protein kinase binding | enzyme binding | ribonucleotide binding | nucleotide binding | hydrolase activity | myosin binding | carbohydrate derivative binding | pyrophosphatase activity | catalytic activity | protein domain specific binding | cytoskeletal protein binding | anion binding | nucleoside-triphosphatase activity | purine nucleotide binding | Rho GDP-dissociation inhibitor binding | ion binding | organic cyclic compound binding | GTPase activity | purine nucleoside binding | purine ribonucleoside triphosphate binding | GDP-dissociation inhibitor binding | protein binding | GTP binding | hydrolase activity, acting on acid anhydrides | nucleoside binding | purine ribonucleotide binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | guanyl nucleotide binding | small molecule binding
GO Biological Process
protein modification by small protein removal | mitotic cytokinesis | mitotic cleavage furrow formation | negative regulation of phosphorylation | brain development | regulation of supramolecular fiber organization | purine ribonucleotide metabolic process | regulation of blood vessel diameter | cell morphogenesis | regulation of muscle system process | regulation of cell cycle process | forebrain radial glial cell differentiation | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | regulation of cysteine-type endopeptidase activity | positive regulation of blood circulation | actin filament-based process | exocytosis | microtubule cytoskeleton organization involved in mitosis | regulation of systemic arterial blood pressure by hormone | response to cytokine | positive regulation of cellular component organization | cell motility | regulation of cell morphogenesis | regulation of neurogenesis | neuron projection morphogenesis | neutrophil activation | response to lipopolysaccharide | muscle tissue development | intracellular signal transduction | positive regulation of apoptotic process | proteolysis | regulation of cell development | regulation of localization | cell-substrate adhesion | actin filament bundle organization | morphogenesis of an epithelium | regulation of programmed cell death | T cell lineage commitment | actin cytoskeleton organization | establishment of localization | regulation of osteoblast proliferation | regulation of immune system process | response to hormone | regulation of cell shape | negative regulation of neuron death | negative regulation of cellular process | positive regulation of developmental process | negative regulation of cell migration involved in sprouting angiogenesis | response to metal ion | positive regulation of lymphocyte activation | bone development | microtubule cytoskeleton organization | cell differentiation | regulation of T cell differentiation | nervous system development | regulation of smooth muscle contraction | response to drug | androgen receptor signaling pathway | regulation of sprouting angiogenesis | epithelial cell migration | cell part morphogenesis | positive regulation of axonogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | regulation of organelle organization | positive regulation of cellular component movement | regulation of actin polymerization or depolymerization | establishment or maintenance of apical/basal cell polarity | generation of neurons | membrane organization | response to antibiotic | hormone-mediated signaling pathway | microtubule-based process | positive regulation of T cell differentiation | regulation of neuron death | positive regulation of cellular biosynthetic process | cellular process | secretion | positive regulation of actin filament polymerization | negative regulation of axonogenesis | lymphocyte differentiation | leukocyte degranulation | regulation of cell motility | localization | cell projection morphogenesis | epithelial tube morphogenesis | cytokinetic process | odontogenesis | forebrain cell migration | nucleotide metabolic process | negative regulation of signaling | neuron development | cytoskeleton-dependent cytokinesis | epithelium migration | immune system development | ribose phosphate metabolic process | positive regulation of protein kinase activity | negative regulation of apoptotic process | response to hypoxia | regulation of proteolysis | nucleoside triphosphate metabolic process | regulation of cell cycle | response to growth factor | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | negative regulation of cell migration | ribonucleotide metabolic process | regulation of neuron projection development | positive regulation of cell division | response to inorganic substance | spindle assembly | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | interspecies interaction between organisms | regulation of oxidative phosphorylation | muscle structure development | positive regulation of vasoconstriction | cell junction assembly | skeletal muscle organ development | positive regulation of cytokinesis | negative regulation of cell motility | regulation of angiogenesis | morphogenesis of a polarized epithelium | regulation of cellular process | leukocyte activation | positive regulation of cell growth | regulation of apoptotic process | cellular response to lipid | regulation of metabolic process | gliogenesis | regulation of protein complex assembly | cellular response to molecule of bacterial origin | polarized epithelial cell differentiation | small GTPase mediated signal transduction | organic cyclic compound metabolic process | trabecula morphogenesis | positive regulation of translation | positive regulation of cellular protein metabolic process | epithelium development | cellular aromatic compound metabolic process | regulation of establishment of planar polarity | ephrin receptor signaling pathway | establishment of cell polarity | cellular component organization | negative regulation of nucleotide metabolic process | angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure | protein deubiquitination | negative regulation of cell morphogenesis involved in differentiation | regulation of systemic arterial blood pressure mediated by a chemical signal | response to transforming growth factor beta | cellular response to metal ion | regulation of cell division | T cell activation | regulation of actin filament length | head development | regulation of vascular smooth muscle contraction | skeletal muscle satellite cell migration | regulation of vasculature development | response to stimulus | positive regulation of blood pressure | purine nucleotide metabolic process | wound healing, spreading of cells | positive regulation of NIK/NF-kappaB signaling | neutrophil degranulation | positive regulation of immune system process | positive regulation of protein metabolic process | positive regulation of peptidase activity | mitotic spindle organization | negative regulation of cell adhesion | regulation of blood vessel size | regulation of modification of synaptic structure | response to stress | mitotic cytokinetic process | regulation of intracellular steroid hormone receptor signaling pathway | endothelial cell migration | leukocyte activation involved in immune response | positive regulation of T cell migration | skeletal muscle tissue development | posttranscriptional regulation of gene expression | regulation of cell proliferation | negative regulation of neuron projection development | positive regulation of actin filament bundle assembly | negative regulation of angiogenesis | tube morphogenesis | regulation of blood circulation | positive regulation of cell-cell adhesion | positive regulation of cysteine-type endopeptidase activity | response to glucose | telencephalon cell migration | phosphatidylinositol-mediated signaling | supramolecular fiber organization | positive regulation of cell activation | cellular response to inorganic substance | secretion by cell | response to alcohol | positive regulation of proteolysis | midbrain development | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | positive regulation of lipase activity | positive regulation of T cell activation | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | negative regulation of metabolic process | regulation of cellular component size | positive regulation of protein serine/threonine kinase activity | hemopoiesis | cellular component assembly | protein modification process | steroid hormone mediated signaling pathway | regulation of synapse structure or activity | regulation of cell adhesion | Wnt signaling pathway, planar cell polarity pathway | purine nucleoside metabolic process | negative regulation of reactive oxygen species biosynthetic process | macromolecule modification | cell-cell signaling | cell surface receptor signaling pathway involved in cell-cell signaling | epiboly | regulation of lymphocyte differentiation | stress-activated protein kinase signaling cascade | response to ethanol | positive regulation of stress fiber assembly | negative regulation of blood vessel diameter | regulation of nucleic acid-templated transcription | leukocyte differentiation | establishment or maintenance of actin cytoskeleton polarity | locomotion | response to nitrogen compound | negative regulation of neuron apoptotic process | organelle assembly | cellular response to hormone stimulus | cleavage furrow formation | response to external biotic stimulus | system development | response to oxygen levels | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | endothelium development | cellular response to chemokine | Wnt signaling pathway | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | regulation of adherens junction organization | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of ATP metabolic process | cell migration | positive regulation of lymphocyte differentiation | regulation of peptidase activity | phosphorus metabolic process | response to amino acid | positive regulation of organelle assembly | regulation of actin filament organization | actin filament organization | regulation of axonogenesis | positive regulation of podosome assembly | leukocyte mediated immunity | regulation of muscle contraction | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of actomyosin structure organization | regulation of phosphorylation | positive regulation of lymphocyte migration | wound healing | regulation of T cell activation | telencephalon development | positive regulation of cell cycle | positive regulation of alpha-beta T cell differentiation | regulation of small GTPase mediated signal transduction | regulation of neuron differentiation | regulation of gene expression | cellular response to stress | response to lipid | cell cycle | regulation of blood pressure | alpha-beta T cell lineage commitment | regulation of systemic arterial blood pressure by renin-angiotensin | organophosphate metabolic process | regulation of systemic arterial blood pressure | nucleoside metabolic process | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of lymphocyte activation | animal organ morphogenesis | regulation of synapse organization | regulation of nitrogen compound metabolic process | regulation of cell migration | regulation of cell-substrate adhesion | enzyme linked receptor protein signaling pathway | regulation of cysteine-type endopeptidase activity involved in apoptotic process | small molecule metabolic process | apical junction assembly | positive regulation of cell projection organization | establishment or maintenance of monopolar cell polarity | positive regulation of intracellular signal transduction | positive regulation of protein complex assembly | response to corticosteroid | vesicle-mediated transport | substantia nigra development | regulation of cellular component movement | regulation of transcription by RNA polymerase II | alpha-beta T cell differentiation | actin filament bundle assembly | morphogenesis of an epithelial sheet | regulation of cell migration involved in sprouting angiogenesis | radial glial cell differentiation | positive regulation of hydrolase activity | positive regulation of cell differentiation | regulation of endothelial cell migration | nucleobase-containing small molecule metabolic process | non-canonical Wnt signaling pathway | positive regulation of cell migration | negative regulation of intracellular steroid hormone receptor signaling pathway | cellular response to cytokine stimulus | negative regulation of epithelial cell migration | cell division | regulation of cellular protein metabolic process | negative regulation of cell-substrate adhesion | glial cell differentiation | vasoconstriction | cytokinesis | actomyosin structure organization | regulated exocytosis | positive regulation of endopeptidase activity | inositol lipid-mediated signaling | positive regulation of neuron death | response to toxic substance | regulation of systemic arterial blood pressure by endothelin | cerebral cortex cell migration | positive regulation of cysteine-type endopeptidase activity involved in apoptotic process | establishment or maintenance of cell polarity | regulation of leukocyte migration | phosphate-containing compound metabolic process | response to bacterium | negative regulation of blood vessel endothelial cell migration | striated muscle tissue development | endocrine process | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | positive regulation of smooth muscle contraction | GTP metabolic process | transmembrane receptor protein serine/threonine kinase signaling pathway | regulation of cytokinesis | regulation of neuron apoptotic process | regulation of actin filament polymerization | negative regulation of oxidative phosphorylation | regulation of alpha-beta T cell differentiation | regulation of T cell migration | cell activation involved in immune response | contractile actin filament bundle assembly | positive regulation of cytoskeleton organization | regulation of NIK/NF-kappaB signaling | myeloid cell activation involved in immune response | regulation of protein metabolic process | positive regulation of signal transduction | neutrophil activation involved in immune response | response to monosaccharide | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | regulation of tube size | viral process | cerebral cortex development | negative regulation of sprouting angiogenesis | ossification involved in bone maturation | positive regulation of systemic arterial blood pressure | regulation of microtubule-based process | lymphocyte activation | positive regulation of molecular function | cellular response to transforming growth factor beta stimulus | neuron differentiation | T cell differentiation | regulation of podosome assembly | regulation of cell morphogenesis involved in differentiation | protein metabolic process | positive regulation of protein modification process | regulation of growth | cellular response to calcium ion | T cell selection | response to organic substance | negative regulation of cell projection organization | Roundabout signaling pathway | tissue morphogenesis | regulation of hemopoiesis | Rho protein signal transduction | regulation of kinase activity | response to wounding | response to mechanical stimulus | regulation of animal organ morphogenesis | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of focal adhesion assembly | positive regulation of neuron apoptotic process | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | positive regulation of neurogenesis | regulation of vasoconstriction | apolipoprotein A-I-mediated signaling pathway | regulation of neural precursor cell proliferation | nuclear division | endothelial tube morphogenesis | cell projection organization | metabolic process | positive regulation of cell development | cell fate commitment | positive regulation of supramolecular fiber organization | negative regulation of I-kappaB kinase/NF-kappaB signaling | cell-cell junction assembly | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | developmental maturation | establishment or maintenance of epithelial cell apical/basal polarity | negative regulation of programmed cell death | negative regulation of cell size | regulation of tube diameter | membrane invagination | actin cytoskeleton reorganization | forebrain generation of neurons | positive regulation of cell death | cell adhesion | immune response | establishment of monopolar cell polarity | nucleobase-containing compound metabolic process | neuron projection development | positive regulation of muscle contraction | positive regulation of cellular component biogenesis | organic substance metabolic process | beta selection | negative regulation of biosynthetic process | animal organ development | forebrain development | negative regulation of neuron differentiation | pallium development | establishment of epithelial cell polarity | endothelial tube lumen extension | regulation of cell activation | negative regulation of cellular component movement | positive regulation of leukocyte migration | positive regulation of programmed cell death | positive regulation of kinase activity | alpha-beta T cell activation | protein modification by small protein conjugation or removal | regulation of ATP metabolic process | regulation of phosphate metabolic process | cytoskeleton organization | cellular response to steroid hormone stimulus | renal system process | mitotic nuclear division | cell activation | intracellular receptor signaling pathway | regulation of reactive oxygen species biosynthetic process | transforming growth factor beta receptor signaling pathway | regulation of stress fiber assembly | regulation of dendrite development | regulation of epithelial cell migration | establishment of apical/basal cell polarity | bone maturation | regulation of cell communication | regulation of blood vessel endothelial cell migration | negative regulation of signal transduction | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of growth | regulation of transcription, DNA-templated | cell-matrix adhesion | response to organic cyclic compound | cell development | positive regulation of phosphorylation | cellular protein metabolic process | regulation of cell size | anatomical structure morphogenesis | regulation of endopeptidase activity | stress fiber assembly | regulation of actin filament bundle assembly | response to biotic stimulus | regulation of nervous system development | regulation of developmental process | regulation of ion transport | renal system process involved in regulation of systemic arterial blood pressure | developmental process | organelle organization | positive regulation of alpha-beta T cell activation | positive regulation of cell cycle process | regulation of cell growth | regulation of calcium ion transport | intracellular steroid hormone receptor signaling pathway | cellular protein modification process | vascular endothelial growth factor receptor signaling pathway | negative chemotaxis | tube development | regulation of cell junction assembly | carbohydrate derivative metabolic process | regulation of transport | regulation of reactive oxygen species metabolic process | regulation of cell-cell adhesion | positive regulation of protein polymerization | negative regulation of vasculature development | Ras protein signal transduction | negative regulation of endothelial cell migration | neutrophil mediated immunity | response to organonitrogen compound | epithelial cell differentiation | establishment or maintenance of cytoskeleton polarity | heterocycle metabolic process | response to calcium ion | mitotic spindle assembly | central nervous system development | transmembrane receptor protein tyrosine kinase signaling pathway | regulation of generation of precursor metabolites and energy | positive regulation of metabolic process | regulation of actin filament-based process | ossification | positive regulation of neuron differentiation | regulation of cell projection organization | skeletal system development | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | ameboidal-type cell migration | cellular response to organic substance | regulation of cell death | positive regulation of cell motility | response to carbohydrate | response to steroid hormone | regulation of organelle assembly | establishment of epithelial cell apical/basal polarity | positive regulation of cell morphogenesis involved in differentiation | regulation of translation | regulation of blood vessel diameter by renin-angiotensin | negative regulation of cell death | negative regulation of cell development | spindle organization | chemotaxis | negative regulation of locomotion | positive regulation of leukocyte cell-cell adhesion | positive regulation of vascular smooth muscle contraction | regulation of microtubule cytoskeleton organization | regulation of lymphocyte migration | regulation of I-kappaB kinase/NF-kappaB signaling | negative regulation of cell differentiation | regulation of cellular component organization | muscle organ development | regulation of cytoskeleton organization | response to other organism | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | neural nucleus development | signal transduction | regulation of signaling | positive regulation of gene expression | response to glucocorticoid | regulation of cell-matrix adhesion | cellular response to growth factor stimulus | cellular response to lipopolysaccharide | macromolecule metabolic process | negative regulation of neurogenesis | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | dendritic spine | cleavage furrow | cytoplasmic side of plasma membrane | dendrite | intracellular membrane-bounded organelle | synapse | neuron projection | extrinsic component of membrane | ruffle | somatodendritic compartment | adherens junction | organelle membrane | cell projection membrane | tertiary granule | focal adhesion | cytoplasmic vesicle | cell | cytoplasmic side of membrane | extrinsic component of plasma membrane | ruffle membrane | lamellipodium | cytoplasm | cell-substrate junction | intracellular organelle | endoplasmic reticulum | dendritic tree | secretory granule membrane | ficolin-1-rich granule membrane | leading edge membrane | cell-cell junction | nuclear outer membrane-endoplasmic reticulum membrane network | cell projection | secretory vesicle | endomembrane system | neuron spine | endoplasmic reticulum membrane | postsynapse | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | midbody | cell leading edge | vesicle | extracellular exosome | cytoplasmic region | endosome | extracellular region | cell cortex | membrane-bounded organelle | extracellular vesicle | apical junction complex | nucleus | organelle | vesicle membrane | cell division site | extracellular space | cell periphery | axon | cell-substrate adherens junction | cytosol | intracellular vesicle | cytoskeleton | intracellular | cell junction | membrane | cytoplasmic vesicle membrane
