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PubChem Substance
Name: rituximab
PubChem Substance ID: 17397150
Rituxan; Rituximab; D02994; Rituximab (genetical recombination); 174722-31-7; Rituximab (genetical recombination) (JAN); Rituxan (TN); Rituximab (USAN)
Name: rituximab
Name (isomeric): DB00073
Drug Type: biotech
AntiCD20; Ig gamma-1 chain C region
Brand: Rituxan, MabThera
Category: Antineoplastic Agents
CAS number: 174722-31-7
Indication: For treatment of CD20-positive non-Hodgkins lymphoma, chronic lymphocytic leukemia, and rheumatoid arthritis.
Pharmacology: Rituximab binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin's lympohomas. The antibody leads to selective killing of B-cells.
Mechanism of Action: The Fab regions of rituximab binds to the CD20 antigen on B lymphocytes, while the Fc domain recruits antibodies and complements to mediate cell lysis.
Biotransformation: Most likely removed by opsonization via the reticuloendothelial system when bound to B lymphocytes, or by human antimurine antibody production
Half Life: 0.8 hours (mammalian reticulocytes, in vitro)
Clearance: 0.34 L/day [RA patients]
Affected organisms: Humans and other mammals
Drug interaction:
VerapamilVerapamil may increase the hypotensive effects of Rituximab. Consider withholding Verapamil therapy for 12 hours prior to Rituximab infusion.
TelmisartanTelmisartan may increase the hypotensive effect of Rituximab. Telmisartan should be withheld prior to and throughout Rituximab administration.
BetaxololAntihypertensives like betaxolol may enhance the hypotensive effect of rituximab. Consider temporarily withholding antihypertensive medications for 12 hours prior to rituximab infusion to avoid excessive hypotension during or immediately after infusion.
TrastuzumabTrastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
TorasemideAdditive antihypertensive effects may occur. Increased risk of hypotension. Consider withholding Torasemide for 12 hours prior to administration of Rituximab.
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