QuickView for Runx3 (gene)

Gene Symbol:

RUNX3 Homo sapiens

Full name:

runt related transcription factor 3

Synonyms:

AML2, CBFA3, PEBP2aC, runt-related transcription factor 3, CBF-alpha-3, PEA2 alpha C, PEBP2 alpha C, SL3-3 enhancer factor 1 alpha C subunit, SL3/AKV core-binding factor alpha C subunit, acute myeloid leukemia 2 protein, acute myeloid leukemia gene 2, core-binding factor subunit alpha-3, core-binding factor, runt domain, alpha subunit 3, oncogene AML-2, polyomavirus enhancer-binding protein 2 alpha C subunit, transcription factor AML2

Genomic Location:

Chr 1: 25098589-25164088

Description:

This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription fact...

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This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

YTCCCRNNAGGY_UNKNOWN ,  TTTGCAC_MIR19A_MIR19B ,  STAT4_01 ,  CCCAGAG_MIR326 ,  TTANTCA_UNKNOWN ,  RYTTCCTG_ETS2_B ,  STAT6_02 ,  CTTTGCA_MIR527 ,  PEA3_Q6 ,  ARP1_01 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  CTTTGA_LEF1_Q2 ,  CTCNANGTGNY_UNKNOWN ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  LEF1_Q2 ,  GTTTGTT_MIR495 ,  RAAGNYNNCTTY_UNKNOWN ,  YCATTAA_UNKNOWN ,  STAT_01 ,  AHR_01 ,  MYOGENIN_Q6 ,  TGCTTTG_MIR330 ,  CAGCTG_AP4_Q5 ,  MZF1_02 ,  TGACATY_UNKNOWN ,  CRX_Q4 ,  AGGAAGC_MIR5163P ,  GGGTGGRR_PAX4_03 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-330

Cytogenetic Map:

1p36.11

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