QuickView for S-adenosyl-l-homocysteine hydrolase (gene)

Gene Symbol:

AHCY Homo sapiens

Full name:

adenosylhomocysteinase

Synonyms:

SAHH, adoHcyase, adenosylhomocysteinase, S-adenosyl-L-homocysteine hydrolase, S-adenosylhomocysteine hydrolase

Genomic Location:

Chr 20: 32331737-32354784

Description:

S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in th...

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S-adenosylhomocysteine hydrolase belongs to the adenosylhomocysteinase family. It catalyzes the reversible hydrolysis of S-adenosylhomocysteine (AdoHcy) to adenosine (Ado) and L-homocysteine (Hcy). Thus, it regulates the intracellular S-adenosylhomocysteine (SAH) concentration thought to be important for transmethylation reactions. Deficiency in this protein is one of the different causes of hypermethioninemia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

OCT1_04 ,  GGGCGGR_SP1_Q6 ,  CTTTAAR_UNKNOWN ,  ATACTGT_MIR144 ,  OCT1_02

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-144

Cytogenetic Map:

20q11.22

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