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QuickView for SCN4B (gene)


Gene Symbol:
SCN4B Homo sapiens Homo sapiens
Full name:
sodium voltage-gated channel beta subunit 4
Synonyms:
ATFB17, LQT10, Navbeta4, sodium channel subunit beta-4, sodium channel, voltage-gated, type IV, beta subunit
Genomic Location:
Chr 11: 117509302-117528747
Description:
The protein encoded by this gene is one of several sodium channel beta subunits. These subunits interact with voltage-gated alpha subunits to change sodium channel kinetics. The encoded transmembrane protein forms interchain disulfide bonds with SCN2A. Defects in this gene are a cause of long QT syndrome type 10 (LQT10). Three protein-coding and on...
Orthologs:
Mus musculus Rattus norvegicus Gallus gallus Bos taurus Danio rerio Pan troglodytes
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 11
11q23.3





GO Molecular Function

voltage-gated ion channel activity | channel regulator activity | passive transmembrane transporter activity | sodium channel regulator activity | voltage-gated sodium channel activity | transmembrane transporter activity | ion gated channel activity | molecular function regulator | ion channel binding | cation transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | voltage-gated sodium channel activity involved in cardiac muscle cell action potential | protein binding | metal ion transmembrane transporter activity | sodium ion transmembrane transporter activity | sodium channel activity | cation channel activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | voltage-gated channel activity | channel activity | ion channel activity | substrate-specific channel activity

GO Biological Process

regulation of ventricular cardiac muscle cell membrane repolarization | heart process | actin filament-based process | regulation of sodium ion transmembrane transporter activity | regulation of localization | regulation of sodium ion transport | establishment of localization | membrane depolarization during action potential | voltage-gated ion channel activity | AV node cell to bundle of His cell signaling | cellular process | channel regulator activity | localization | passive transmembrane transporter activity | regulation of sodium ion transmembrane transport | metal ion transport | actin filament-based movement | sodium channel regulator activity | membrane depolarization during cardiac muscle cell action potential | voltage-gated sodium channel activity | transmembrane transporter activity | heart contraction | actin-mediated cell contraction | muscle contraction | ion gated channel activity | regulation of blood circulation | regulation of heart rate | blood circulation | cell-cell signaling | molecular function regulator | regulation of membrane potential | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | cardiac muscle cell action potential involved in contraction | ion transmembrane transporter activity | voltage-gated sodium channel activity involved in cardiac muscle cell action potential | cell-cell signaling involved in cardiac conduction | regulation of heart contraction | cell communication | cardiac muscle cell contraction | positive regulation of transport | striated muscle contraction | cation transmembrane transport | regulation of heart rate by cardiac conduction | metal ion transmembrane transporter activity | AV node cell action potential | AV node cell to bundle of His cell communication | cell communication involved in cardiac conduction | membrane depolarization | sodium ion transmembrane transport | positive regulation of ion transport | positive regulation of sodium ion transport | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | regulation of ion transmembrane transport | sodium channel activity | cation channel activity | transmembrane transport | action potential | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | voltage-gated channel activity | cation transport | channel activity | regulation of ion transport | regulation of transport | cardiac muscle cell action potential | ion channel activity | ion transport | cardiac muscle contraction | substrate-specific channel activity | regulation of membrane repolarization | muscle system process | cardiac conduction | multicellular organismal process

GO Cellular Component

intercalated disc | integral component of membrane | voltage-gated sodium channel complex | cell | plasma membrane protein complex | intrinsic component of membrane | cell-cell junction | cell-cell contact zone | protein-containing complex | plasma membrane | integral component of plasma membrane | sodium channel complex | cell periphery | transmembrane transporter complex | cation channel complex | ion channel complex | cell junction | membrane | intrinsic component of plasma membrane