QuickView for SCRIB;jsessionid=E3140089D06F67708964EBBFAC0287D0 (gene)

Gene Symbol:

SCRIB Homo sapiens

Full name:

scribbled planar cell polarity protein

Synonyms:

CRIB1, SCRB1, SCRIB1, Vartul, protein scribble homolog, scribbled homolog

Genomic Location:

Chr 8: 144945078-144969537

Description:

This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and ...

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This gene encodes a protein that was identified as being similar to the Drosophila scribble protein. The mammalian protein is involved in tumor suppression pathways. As a scaffold protein involved in cell polarization processes, this protein binds to many other proteins. The encoded protein binds to papillomavirus E6 protein via its PDZ domain and the C-terminus of E6. Two alternatively spliced transcript variants that encode different protein isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

8q24.3

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