QuickView for SDCBP;jsessionid=546F649770729EDEECC87F580F6DE192 (gene)

Gene Symbol:

SDCBP Homo sapiens

Full name:

syndecan binding protein

Synonyms:

MDA-9, MDA9, ST1, SYCL, TACIP18, syntenin-1, melanoma differentiation associated protein-9, pro-TGF-alpha cytoplasmic domain-interacting protein 18, scaffold protein Pbp1, syndecan binding protein (syntenin), syndecan-binding protein 1

Genomic Location:

Chr 8: 59628282-59657973

Description:

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhes...

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The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. Related pseudogenes have been identified on multiple chromosomes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  AP1_C ,  STAT4_01 ,  TGANTCA_AP1_C ,  AAGCCAT_MIR135A_MIR135B ,  STAT6_02 ,  ACTTTAT_MIR1425P ,  AGCATTA_MIR155 ,  AP1_Q6_01 ,  AP1FJ_Q2 ,  ACTACCT_MIR196A_MIR196B ,  AAAYRNCTG_UNKNOWN ,  AP1_Q2 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-196 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

8q12.1

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