QuickView for SDHC (gene)

Gene Symbol:

SDHC Homo sapiens

Full name:

succinate dehydrogenase complex subunit C

Synonyms:

CYB560, CYBL, PGL3, QPS1, SDH3, succinate dehydrogenase cytochrome b560 subunit, mitochondrial, cytochrome B large subunit of complex II, integral membrane protein CII-3b, large subunit of cytochrome b, succinate dehydrgenase cytochrome b, succinate dehydrogenase 3, integral membrane subunit, succinate dehydrogenase complex subunit C integral membrane protein 15kDa, succinate dehydrogenase complex, subunit C, integral membrane protein, 15kD, succinate-ubiquinone oxidoreductase cytochrome B large subunit

Genomic Location:

Chr 1: 159550790-159601165

Description:

This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form ...

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This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  STAT1_02 ,  TCANNTGAY_SREBP1_01 ,  FOXJ2_02 ,  YTATTTTNR_MEF2_02 ,  RSRFC4_Q2 ,  CTTTGA_LEF1_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  LEF1_Q2 ,  CAGCTTT_MIR320 ,  ACTGCCT_MIR34B ,  OCT1_02 ,  CTTTGT_LEF1_Q2 ,  AACTTT_UNKNOWN

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-34b

Cytogenetic Map:

1q23.3

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