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QuickView for SERCA2a (gene)


Gene Symbol:
Atp2a2 Mus musculus Mus musculus
Full name:
ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Synonyms:
9530097L16Rik, D5Wsu150e, SERCA2, SERCA2B, Serca2a, mKIAA4195, sarcoplasmic/endoplasmic reticulum calcium ATPase 2, SERCA2a isoform, SR Ca(2+)-ATPase 2, calcium pump 2, calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform, endoplasmic reticulum class 1/2 Ca(2+) ATPase, sarco/endoplasmic reticulum Ca2+-ATPase 2
Genomic Location:
Chr 5: 122903523-122951904
Orthologs:
Homo sapiens Rattus norvegicus Danio rerio Gallus gallus Canis lupus familiaris Pan troglodytes Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
ZID_01 HFH1_01 FOXD3_01 SRY_01 OCT1_05 OCT1_Q6 SP1_Q6 EGR2_01 AML1_01 NFY_01
miRNA binding sites
(Source: TargetScan):


Transcripts Names
NM_009722
NM_001110140
NR_027838
Protein Names
Q9R2A9
O55143
Q9WUT5
Q5DTI2



GO Molecular Function

ATPase activity, coupled to transmembrane movement of substances | proton transmembrane transporter activity | cation binding | S100 protein binding | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | enzyme binding | ribonucleotide binding | transmembrane transporter activity | nucleotide binding | signaling receptor binding | proton-exporting ATPase activity, phosphorylative mechanism | hydrolase activity | calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential | carbohydrate derivative binding | ATPase activity | pyrophosphatase activity | lutropin-choriogonadotropic hormone receptor binding | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | nucleoside-triphosphatase activity | cation transmembrane transporter activity | ATPase activity, coupled | proton-exporting ATPase activity | cation-transporting ATPase activity | active transmembrane transporter activity | purine nucleotide binding | transporter activity | calcium ion transmembrane transporter activity | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | calcium-transporting ATPase activity | metal ion transmembrane transporter activity | G-protein coupled receptor binding | hydrolase activity, acting on acid anhydrides | calcium ion binding | ATPase coupled ion transmembrane transporter activity | inorganic cation transmembrane transporter activity | purine ribonucleotide binding | monovalent inorganic cation transmembrane transporter activity | adenyl ribonucleotide binding | drug binding | metal ion binding | heterocyclic compound binding | hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | protein C-terminus binding | small molecule binding

GO Biological Process

ATP hydrolysis coupled cation transmembrane transport | regulation of muscle system process | regulation of cellular localization | intracellular signal transduction | cytosolic calcium ion transport | regulation of localization | ATPase activity, coupled to transmembrane movement of substances | establishment of localization | proton transmembrane transporter activity | response to hormone | cell differentiation | cellular chemical homeostasis | relaxation of cardiac muscle | membrane organization | intracellular transport | calcium ion import | cellular process | proton transmembrane transport | localization | cellular homeostasis | metal ion transport | regulation of skeletal muscle adaptation | endomembrane system organization | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism | establishment of localization in cell | response to peptide hormone | muscle structure development | muscle cell differentiation | T-tubule organization | regulation of cellular process | transmembrane transporter activity | cellular component organization | calcium ion homeostasis | response to stimulus | muscle cell development | ATP hydrolysis coupled transmembrane transport | proton-exporting ATPase activity, phosphorylative mechanism | response to stress | calcium-transporting ATPase activity involved in regulation of cardiac muscle cell membrane potential | regulation of cardiac muscle contraction by calcium ion signaling | regulation of blood circulation | regulation of cardiac muscle cell contraction | response to peptide | cellular localization | divalent metal ion transport | regulation of cardiac muscle cell membrane potential | modulation of chemical synaptic transmission | regulation of intracellular transport | metal ion homeostasis | regulation of membrane potential | regulation of neurotransmitter levels | response to nitrogen compound | calcium ion transmembrane transport | regulation of synaptic vesicle exocytosis | relaxation of muscle | regulation of muscle contraction | cellular response to oxidative stress | ER-nucleus signaling pathway | ATP hydrolysis coupled ion transmembrane transport | ion transmembrane transport | plasma membrane organization | cellular response to stress | cation transmembrane transporter activity | proton-exporting ATPase activity | cellular ion homeostasis | cation-transporting ATPase activity | monovalent inorganic cation transport | regulation of calcium ion-dependent exocytosis of neurotransmitter | active transmembrane transporter activity | regulation of cellular component movement | calcium ion transmembrane transporter activity | response to oxidative stress | regulation of the force of heart contraction | ion transmembrane transporter activity | second-messenger-mediated signaling | cardiac muscle hypertrophy | calcium ion import into sarcoplasmic reticulum | regulation of synaptic vesicle transport | regulation of heart contraction | cation homeostasis | regulation of striated muscle contraction | cellular cation homeostasis | cell communication | regulation of cardiac muscle contraction | regulation of cardiac muscle cell action potential | cellular calcium ion homeostasis | homeostatic process | calcium-mediated signaling | cation transmembrane transport | transition between fast and slow fiber | positive regulation of endoplasmic reticulum calcium ion concentration | calcium-transporting ATPase activity | response to organic substance | metal ion transmembrane transporter activity | regulation of exocytosis | anatomical structure development | negative regulation of heart contraction | regulation of vesicle-mediated transport | chemical homeostasis | calcium ion transport | regulation of secretion | ion homeostasis | inorganic cation transmembrane transport | regulation of regulated secretory pathway | regulation of action potential | regulation of cell communication | ATPase coupled ion transmembrane transporter activity | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | sarcoplasmic reticulum calcium ion transport | cell development | cation transport | endoplasmic reticulum calcium ion homeostasis | developmental process | organelle organization | regulation of transport | response to organonitrogen compound | cellular metal ion homeostasis | regulation of calcium ion-dependent exocytosis | regulation of actin filament-based process | ion transport | muscle hypertrophy | divalent inorganic cation homeostasis | muscle system process | cardiac muscle hypertrophy in response to stress | regulation of cardiac muscle cell action potential involved in regulation of contraction | signal transduction | regulation of signaling | regulation of neurotransmitter secretion | calcium ion transport from cytosol to endoplasmic reticulum | multicellular organismal process

GO Cellular Component

intercalated disc | integral component of membrane | cytoplasmic side of plasma membrane | sarcoplasmic reticulum | intracellular membrane-bounded organelle | synapse | catalytic complex | extrinsic component of membrane | organelle membrane | cell | cytoplasmic side of membrane | nuclear lumen | extrinsic component of plasma membrane | intrinsic component of membrane | cytoplasm | intracellular organelle | endoplasmic reticulum | cell-cell junction | cell-cell contact zone | cation-transporting ATPase complex | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | endomembrane system | endoplasmic reticulum membrane | nucleoplasm | plasma membrane | extrinsic component of cytoplasmic side of plasma membrane | calcium ion-transporting ATPase complex | vesicle | perinuclear region of cytoplasm | membrane-bounded organelle | sarcoplasmic reticulum membrane | nucleus | organelle | vesicle membrane | sarcoplasm | cell periphery | longitudinal sarcoplasmic reticulum | membrane-enclosed lumen | transmembrane transporter complex | ATPase complex | ribbon synapse | intracellular | cell junction | membrane