QuickView for SERPINA7 (gene)

Gene Symbol:

SERPINA7 Homo sapiens

Full name:

serpin family A member 7

Synonyms:

TBG, TBGQTL, thyroxine-binding globulin, T4-binding globulin, mutant serpin family A member 7, serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7, serpin A7, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7, thyroxin-binding globulin

Genomic Location:

Chr X: 105163853-105167722

Description:

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein ha...

View Full Description

There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPA_01 ,  HNF1_01 ,  CEBP_Q2_01 ,  HNF1_C ,  TTTNNANAGCYR_UNKNOWN ,  TATAAA_TATA_01 ,  CEBP_Q2 ,  CEBPB_02 ,  CEBP_Q3 ,  HNF1_Q6

Cytogenetic Map:

Xq22.3

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