QuickView for SF1 (gene)

Gene Symbol:

SF1 Homo sapiens

Full name:

splicing factor 1

Synonyms:

BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162, splicing factor 1, mammalian branch point-binding protein, transcription factor ZFM1, zinc finger gene in MEN1 locus, zinc finger protein 162

Genomic Location:

Chr 11: 64288654-64302817

Description:

This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional ...

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This gene encodes a nuclear pre-mRNA splicing factor. The encoded protein specifically recognizes the intron branch point sequence at the 3' splice site, together with the large subunit of U2 auxiliary factor (U2AF), and is required for the early stages of spliceosome assembly. It also plays a role in nuclear pre-mRNA retention and transcriptional repression. The encoded protein contains an N-terminal U2AF ligand motif, a central hnRNP K homology motif and quaking 2 region which bind a key branch-site adenosine within the branch point sequence, a zinc knuckles domain, and a C-terminal proline-rich domain. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  NFMUE1_Q6 ,  MAZR_01 ,  TTTGCAG_MIR518A2 ,  RYTTCCTG_ETS2_B ,  PEA3_Q6 ,  CCTGAGT_MIR510 ,  TCCGTCC_MIR184 ,  GGGAGGRR_MAZ_Q6 ,  TFIII_Q6 ,  CAGGTA_AREB6_01 ,  GTGACGY_E4F1_Q6 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  GGCAGAC_MIR346 ,  ETS2_B ,  TGCGCANK_UNKNOWN ,  AHR_Q5 ,  AP2_Q3 ,  KCCGNSWTTT_UNKNOWN ,  NRF1_Q6 ,  TCTCTCC_MIR185 ,  YGCGYRCGC_UNKNOWN ,  GATA4_Q3 ,  GAGCCAG_MIR149 ,  WTTGKCTG_UNKNOWN ,  CAGCCTC_MIR4855P ,  CTTTGT_LEF1_Q2 ,  EGR1_01 ,  RCGCANGCGY_NRF1_Q6 ,  ELF1_Q6 ,  RRCCGTTA_UNKNOWN ,  TATTATA_MIR374 ,  CP2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-103 ,  Predicted Gene Targets for miR-184 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-149 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

11q13.1

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