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QuickView for SFTPA1;jsessionid=7F90671BF94EDD7742B2F6295F244611 (gene)


Gene Symbol:
SFTPA1 Homo sapiens Homo sapiens
Full name:
surfactant protein A1
Synonyms:
COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1, pulmonary surfactant-associated protein A1, 35 kDa pulmonary surfactant-associated protein, SP-A1 beta, SP-A1 delta, SP-A1 epsilon, SP-A1 gamma, alveolar proteinosis protein, collectin-4, surfactant protein A1 variant AB'D' 6A, surfactant protein A1 variant AB'D' 6A2, surfactant protein A1 variant AB'D' 6A3, surfactant protein A1 variant AB'D' 6A4, surfactant protein A1 variant ACD' 6A, surfactant protein A1 variant ACD' 6A2, surfactant protein A1 variant ACD' 6A3, surfactant protein A1 variant ACD' 6A4, surfactant protein A1 variant AD' 6A, surfactant protein A1 variant AD' 6A2, surfactant protein A1 variant AD' 6A3, surfactant protein A1 variant AD' 6A4, surfactant protein A1B, surfactant, pulmonary-associated protein A1A, surfactant, pulmonary-associated protein A1B
Genomic Location:
Chr 10: 81040722-81045208
Description:
This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The encoded protein binds specific carbohydrate moieties found on lipids and on the surface of microorganisms. This protein plays an essential role in surfactant homeostasis and in the defense against respiratory pathogens. Mutations in ...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Bos taurus Canis lupus familiaris Pan troglodytes
External Links:
Entrez Gene
Cytogenetic Map:
chr 10
10q22.3





GO Molecular Function

lipid binding | carbohydrate derivative binding | monosaccharide binding | transporter activity | carbohydrate binding | protein binding | lipopolysaccharide binding | lipid transporter activity | small molecule binding

GO Biological Process

positive regulation of immune response | respiratory gaseous exchange | positive regulation of cellular component organization | immune response-regulating signaling pathway | regulation of localization | lipid transport | establishment of localization | regulation of immune system process | opsonization | tissue homeostasis | innate immune response-activating signal transduction | cellular process | toll-like receptor signaling pathway | localization | macromolecule localization | anatomical structure homeostasis | regulation of immune response | regulation of cellular process | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | multicellular organismal homeostasis | activation of innate immune response | immune response-activating signal transduction | regulation of phagocytosis | chemical homeostasis within a tissue | nitrogen compound metabolic process | pattern recognition receptor signaling pathway | organic substance transport | vesicle-mediated transport | surfactant homeostasis | cell communication | homeostatic process | positive regulation of transport | activation of immune response | protein metabolic process | regulation of innate immune response | import into cell | metabolic process | lipid localization | regulation of vesicle-mediated transport | chemical homeostasis | endocytosis | organic substance metabolic process | positive regulation of phagocytosis | signaling | regulation of endocytosis | cellular protein metabolic process | regulation of transport | lipid transporter activity | immune system process | cellular metabolic process | phagocytosis | positive regulation of endocytosis | regulation of cellular component organization | signal transduction | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

secretory granule | intracellular membrane-bounded organelle | late endosome | clathrin-coated vesicle | cytoplasmic vesicle | cell | multivesicular body | cytoplasm | clathrin-coated endocytic vesicle | intracellular organelle | endoplasmic reticulum | nuclear outer membrane-endoplasmic reticulum membrane network | protein-containing complex | secretory vesicle | endomembrane system | endoplasmic reticulum membrane | vesicle | collagen trimer | endosome | extracellular region | membrane-bounded organelle | organelle | extracellular space | rough endoplasmic reticulum | lamellar body | intracellular vesicle | endocytic vesicle | intracellular | membrane | coated vesicle