QuickView for SH2B3;jsessionid=3D57CC2E5ACE6273C5290C170AB8F4BE (gene)
- Gene Symbol:
- SH2B3
Homo sapiens - Full name:
- SH2B adaptor protein 3
- Synonyms:
- IDDM20, LNK, SH2B adapter protein 3, lymphocyte-specific adapter protein Lnk, signal transduction protein Lnk
- Genomic Location:
- Chr 12: 110328135-110373810
- Description:
-
This gene encodes a member of the SH2B adaptor family of proteins, which are involved in a range of signaling activities by growth factor and cytokine receptors. The encoded protein is a key negative regulator of cytokine signaling and plays a critical role in hematopoiesis. Mutations in this gene have been associated with susceptibility to celiac ...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
12q24.12
GO Molecular Function
kinase binding | protein kinase binding | receptor tyrosine kinase binding | enzyme binding | transmembrane receptor protein tyrosine kinase adaptor activity | signaling receptor binding | signaling adaptor activity | protein binding, bridging | protein tyrosine kinase binding | molecular adaptor activity | protein binding
GO Biological Process
intracellular signal transduction | cell differentiation | cellular process | immune system development | hemostasis | regulation of cellular process | response to stimulus | transmembrane receptor protein tyrosine kinase adaptor activity | response to stress | hemopoiesis | embryo development | blood coagulation | signaling adaptor activity | system development | regulation of signal transduction | multicellular organism development | embryonic hemopoiesis | wound healing | enzyme linked receptor protein signaling pathway | cell communication | positive regulation of signal transduction | coagulation | response to wounding | anatomical structure development | cell surface receptor signaling pathway | regulation of body fluid levels | embryonic organ development | animal organ development | regulation of cell communication | signaling | developmental process | transmembrane receptor protein tyrosine kinase signaling pathway | immune system process | hematopoietic or lymphoid organ development | positive regulation of signaling | signal transduction | regulation of signaling | multicellular organismal process
GO Cellular Component
cell | cytoplasm | plasma membrane | cell periphery | cytosol | intracellular | membrane
