QuickView for SHMT2;jsessionid=59A04712DA58A6C5D6F796FFCDFDE964 (gene)

Gene Symbol:

SHMT2 Homo sapiens

Full name:

serine hydroxymethyltransferase 2

Synonyms:

GLYA, HEL-S-51e, SHMT, serine hydroxymethyltransferase, mitochondrial, GLY A+, epididymis secretory sperm binding protein Li 51e, glycine auxotroph A, human complement for hamster, glycine hydroxymethyltransferase, serine aldolase, serine hydroxymethylase, serine hydroxymethyltransferase 2 (mitochondrial), serine methylase, threonine aldolase

Genomic Location:

Chr 12: 55909819-55914981

Description:

This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source o...

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This gene encodes the mitochondrial form of a pyridoxal phosphate-dependent enzyme that catalyzes the reversible reaction of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. The encoded product is primarily responsible for glycine synthesis. The activity of the encoded protein has been suggested to be the primary source of intracellular glycine. The gene which encodes the cytosolic form of this enzyme is located on chromosome 17. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Schizosaccharomyces pombe ,  Pan troglodytes ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AACWWCAANK_UNKNOWN ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  TCTGATC_MIR383 ,  ACTAYRNNNCCCR_UNKNOWN ,  NRF1_Q6 ,  HLF_01 ,  RCGCANGCGY_NRF1_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-383 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

12q13.3

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