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QuickView for SIN3A;jsessionid=7E2F3F547E520AA5324A79A9E7005B90 (gene)


Gene Symbol:
SIN3A Homo sapiens Homo sapiens
Full name:
SIN3 transcription regulator family member A
Synonyms:
WITKOS, paired amphipathic helix protein Sin3a, SIN3 homolog A, transcription regulator, histone deacetylase complex subunit Sin3a, transcriptional co-repressor Sin3A, transcriptional corepressor Sin3a, transcriptional regulator, SIN3A
Genomic Location:
Chr 15: 73450328-73530979
Description:
The protein encoded by this gene is a transcriptional regulatory protein. It contains paired amphipathic helix (PAH) domains, which are important for protein-protein interactions and may mediate repression by the Mad-Max complex.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 15
15q24.2





GO Molecular Function

sequence-specific DNA binding | transcription regulatory region DNA binding | repressing transcription factor binding | RNA polymerase II activating transcription factor binding | nucleic acid binding | protein-containing complex binding | hydrolase activity | protein deacetylase activity | catalytic activity | chromatin binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | histone deacetylase activity | RNA polymerase II repressing transcription factor binding | DNA binding | sequence-specific double-stranded DNA binding | transcription corepressor activity | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | double-stranded DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | activating transcription factor binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | transcription coregulator activity | heterocyclic compound binding | RNA binding

GO Biological Process

positive regulation of immune response | RNA metabolic process | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | cellular response to glucose stimulus | positive regulation of cellular component organization | regulation of cellular localization | regulation of localization | regulation of programmed cell death | regulation of immune system process | response to dopamine | positive regulation of G2/M transition of mitotic cell cycle | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | response to drug | cellular chemical homeostasis | histone deacetylation | glucose homeostasis | regulation of organelle organization | positive regulation of cellular biosynthetic process | cellular process | localization | cellular homeostasis | chromatin organization | immune system development | negative regulation of nucleic acid-templated transcription | macromolecule localization | regulation of histone modification | negative regulation of apoptotic process | positive regulation of defense response to virus by host | regulation of defense response to virus | regulation of megakaryocyte differentiation | regulation of cell cycle | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of peptidyl-lysine acetylation | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | regulation of immune response | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | RNA biosynthetic process | cellular response to organonitrogen compound | cellular aromatic compound metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | negative regulation of protein localization to nucleus | positive regulation of chromatin silencing | response to stimulus | regulation of cellular protein localization | positive regulation of innate immune response | regulation of mitotic cell cycle phase transition | positive regulation of immune system process | response to stress | negative regulation of circadian rhythm | cellular nitrogen compound biosynthetic process | regulation of cell cycle phase transition | response to glucose | hematopoietic progenitor cell differentiation | regulation of transcription regulatory region DNA binding | activation of innate immune response | cellular localization | regulation of histone H3-K27 acetylation | rhythmic process | regulation of gene silencing | cellular nitrogen compound metabolic process | regulation of DNA binding | cellular response to organic cyclic compound | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | hemopoiesis | protein modification process | protein deacetylase activity | cellular biosynthetic process | embryo development | macromolecule modification | regulation of nucleic acid-templated transcription | response to nitrogen compound | regulation of cell cycle G2/M phase transition | system development | nitrogen compound metabolic process | positive regulation of organelle organization | multicellular organism development | cellular glucose homeostasis | cellular response to oxidative stress | negative regulation of cellular protein localization | regulation of hormone levels | positive regulation of chromosome organization | cellular response to ammonium ion | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | histone deacetylase activity | response to ketone | cellular response to stress | positive regulation of cellular metabolic process | response to ammonium ion | regulation of protein localization to nucleus | regulation of nitrogen compound metabolic process | negative regulation of DNA binding | transcription corepressor activity | regulation of transcription by RNA polymerase II | positive regulation of cell cycle G2/M phase transition | response to oxidative stress | negative regulation of binding | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | biosynthetic process | protein deacetylation | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | negative regulation of transcription regulatory region DNA binding | response to methylglyoxal | cellular response to drug | chordate embryonic development | regulation of cellular metabolic process | response to catecholamine | regulation of protein metabolic process | homeostatic process | response to monosaccharide | embryo development ending in birth or egg hatching | regulation of RNA metabolic process | regulation of mitotic cell cycle | response to monoamine | activation of immune response | protein metabolic process | DNA-binding transcription factor activity | response to organic substance | regulation of innate immune response | regulation of hemopoiesis | DNA metabolic process | anatomical structure development | positive regulation of mitotic cell cycle phase transition | metabolic process | regulation of DNA-templated transcription in response to stress | regulation of chromatin silencing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | cellular protein localization | negative regulation of histone acetylation | cellular response to carbohydrate stimulus | chemical homeostasis | nucleobase-containing compound metabolic process | organic substance metabolic process | negative regulation of histone H3-K27 acetylation | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | negative regulation of cellular protein metabolic process | gene expression | regulation of chromosome organization | transcription, DNA-templated | negative regulation of protein metabolic process | negative regulation of chromosome organization | negative regulation of molecular function | covalent chromatin modification | regulation of transcription, DNA-templated | response to organic cyclic compound | protein localization | cellular protein metabolic process | regulation of transcription from RNA polymerase II promoter in response to stress | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of circadian rhythm | regulation of developmental process | developmental process | organelle organization | positive regulation of cell cycle process | cellular protein modification process | regulation of histone acetylation | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | negative regulation of protein acetylation | response to organonitrogen compound | transcription coregulator activity | positive regulation of transcription by RNA polymerase II | regulation of defense response to virus by host | heterocycle metabolic process | cellular response to dopamine | in utero embryonic development | regulation of lipid metabolic process | positive regulation of metabolic process | chromosome organization | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | cellular response to organic substance | regulation of protein localization | regulation of cell death | response to carbohydrate | DNA replication | negative regulation of cell death | aging | carbohydrate homeostasis | regulation of cellular component organization | cellular response to catecholamine stimulus | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | chromosome, centromeric region | cell | nuclear lumen | kinetochore | transcription factor complex | nucleolus | intracellular organelle | protein-containing complex | histone deacetylase complex | nucleoplasm | chromatin | nuclear chromosome | Sin3 complex | membrane-bounded organelle | transcriptional repressor complex | nucleus | Sin3-type complex | organelle | membrane-enclosed lumen | nuclear chromatin | intracellular