QuickView for SIRT5 (gene)
- Gene Symbol:
- SIRT5
Homo sapiens - Full name:
- sirtuin 5
- Synonyms:
- SIR2L5, NAD-dependent protein deacylase sirtuin-5, mitochondrial, NAD-dependent deacetylase sirtuin-5, NAD-dependent lysine demalonylase and desuccinylase sirtuin-5, mitochondrial, silent mating type information regulation 2, S.cerevisiae, homolog 5, sir2-like 5, sirtuin type 5
- Genomic Location:
- Chr 6: 13682812-13720500
- Description:
-
This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and su...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Danio rerio , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
6p23
GO Molecular Function
cofactor binding | NAD+ ADP-ribosyltransferase activity | cation binding | protein-succinyllysine desuccinylase activity | nucleotide binding | protein-malonyllysine demalonylase activity | coenzyme binding | hydrolase activity | protein deacetylase activity | NAD+ binding | catalytic activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | NAD-dependent protein deacetylase activity | anion binding | transferase activity, transferring glycosyl groups | ion binding | organic cyclic compound binding | protein-glutaryllysine deglutarylase activity | zinc ion binding | NAD binding | transferase activity, transferring pentosyl groups | transferase activity | transition metal ion binding | deacetylase activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
response to extracellular stimulus | response to nutrient levels | protein desuccinylation | regulation of programmed cell death | peptidyl-amino acid modification | negative regulation of cellular process | negative regulation of RNA biosynthetic process | regulation of cardiac muscle cell apoptotic process | peptidyl-lysine deglutarylation | cellular process | regulation of gene expression, epigenetic | chromatin organization | negative regulation of nucleic acid-templated transcription | negative regulation of apoptotic process | negative regulation of cellular metabolic process | regulation of cellular process | regulation of apoptotic process | gene silencing | regulation of metabolic process | cellular component organization | protein-succinyllysine desuccinylase activity | protein-malonyllysine demalonylase activity | response to stimulus | negative regulation of metabolic process | protein modification process | protein deacetylase activity | mitochondrion organization | macromolecule modification | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | NAD-dependent protein deacetylase activity | negative regulation of striated muscle cell apoptotic process | regulation of gene expression | negative regulation of gene expression, epigenetic | regulation of ketone biosynthetic process | regulation of nitrogen compound metabolic process | negative regulation of cardiac muscle cell apoptotic process | protein deacetylation | regulation of muscle cell apoptotic process | regulation of cellular metabolic process | regulation of RNA metabolic process | protein-glutaryllysine deglutarylase activity | protein metabolic process | protein demalonylation | protein ADP-ribosylation | metabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | peptidyl-lysine modification | negative regulation of muscle cell apoptotic process | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of transcription, DNA-templated | cellular protein metabolic process | peptidyl-lysine demalonylation | regulation of cellular ketone metabolic process | organelle organization | cellular protein modification process | regulation of reactive oxygen species metabolic process | chromosome organization | chromatin silencing | cellular metabolic process | regulation of cell death | peptidyl-lysine desuccinylation | negative regulation of cell death | protein deglutarylation | negative regulation of reactive oxygen species metabolic process | macromolecule metabolic process
GO Cellular Component
mitochondrial matrix | mitochondrial intermembrane space | organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cell | cytoplasm | intracellular organelle | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | cytosol | intracellular | membrane
