QuickView for SKP1 (gene)

Gene Symbol:

SKP1 Homo sapiens

Full name:

S-phase kinase associated protein 1

Synonyms:

EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A, S-phase kinase-associated protein 1, OCP-2, RNA polymerase II elongation factor-like protein OCP2, SIII, cyclin A/CDK2-associated p19, cyclin-A/CDK2-associated protein p19, organ of Corti protein 2, organ of Corti protein II, p19skp1, transcription elongation factor B polypeptide 1-like

Genomic Location:

Chr 5: 133520468-133540583

Description:

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for de...

View Full Description

This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  SMAD3_Q6 ,  GCANCTGNY_MYOD_Q6 ,  AACTGGA_MIR145 ,  TAGCTTT_MIR9 ,  TTGCACT_MIR130A_MIR301_MIR130B ,  IRF1_Q6 ,  CATGTAA_MIR496 ,  GTGACGY_E4F1_Q6 ,  CDX2_Q5 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  GTCTTCC_MIR7 ,  POU1F1_Q6 ,  NRF2_Q4 ,  OCT1_02 ,  CTTTGT_LEF1_Q2 ,  TCF11MAFG_01 ,  TGASTMAGC_NFE2_01

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-145 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-496

Cytogenetic Map:

5q31.1

search → result