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QuickView for SKP2 (gene)


Gene Symbol:
SKP2 Homo sapiens Homo sapiens
Full name:
S-phase kinase associated protein 2
Synonyms:
FBL1, FBXL1, FLB1, p45, S-phase kinase-associated protein 2, CDK2/cyclin A-associated protein p45, F-box/LRR-repeat protein 1, S-phase kinase-associated protein 2, E3 ubiquitin protein ligase, p45skp2
Genomic Location:
Chr 5: 36187946-36219904
Description:
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into ...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5p13.2





GO Molecular Function

catalytic activity | ubiquitin-like protein transferase activity | identical protein binding | ubiquitin protein ligase activity | protein binding | ubiquitin-protein transferase activity | transferase activity | ubiquitin-like protein ligase activity

GO Biological Process

protein modification by small protein removal | positive regulation of smooth muscle cell proliferation | response to extracellular stimulus | proteolysis | regulation of programmed cell death | cellular response to extracellular stimulus | cellular process | organic substance catabolic process | proteolysis involved in cellular protein catabolic process | regulation of cell cycle | positive regulation of nitrogen compound metabolic process | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | positive regulation of cellular protein metabolic process | protein deubiquitination | response to stimulus | positive regulation of protein metabolic process | regulation of intracellular steroid hormone receptor signaling pathway | regulation of cell proliferation | positive regulation of protein polyubiquitination | regulation of protein ubiquitination | cellular protein catabolic process | proteasomal protein catabolic process | cell cycle G1/S phase transition | protein modification process | macromolecule modification | nitrogen compound metabolic process | regulation of signal transduction | regulation of intracellular estrogen receptor signaling pathway | cell cycle | protein catabolic process | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | ubiquitin protein ligase activity | cell proliferation | regulation of cellular protein metabolic process | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | G2/M transition of mitotic cell cycle | mitotic cell cycle phase transition | positive regulation of intracellular estrogen receptor signaling pathway | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | cell cycle G2/M phase transition | G1/S transition of mitotic cell cycle | positive regulation of cell proliferation | proteasome-mediated ubiquitin-dependent protein catabolic process | protein polyubiquitination | protein metabolic process | positive regulation of protein modification process | protein ubiquitination | cellular macromolecule catabolic process | mitotic cell cycle | metabolic process | ubiquitin-protein transferase activity | organic substance metabolic process | protein modification by small protein conjugation or removal | ubiquitin-dependent protein catabolic process | organonitrogen compound catabolic process | regulation of cell communication | positive regulation of intracellular steroid hormone receptor signaling pathway | cellular protein metabolic process | cellular protein modification process | cell cycle phase transition | cellular response to cell-matrix adhesion | positive regulation of metabolic process | cellular metabolic process | regulation of cell death | regulation of smooth muscle cell proliferation | modification-dependent protein catabolic process | positive regulation of protein ubiquitination | positive regulation of signaling | regulation of signaling | post-translational protein modification | macromolecule metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | nucleolus | cytoplasm | intracellular organelle | ubiquitin ligase complex | protein-containing complex | nucleoplasm | transferase complex | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | SCF ubiquitin ligase complex | cytosol | intracellular