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QuickView for SLC12A2 (gene)


Gene Symbol:
SLC12A2 Homo sapiens Homo sapiens
Full name:
solute carrier family 12 member 2
Synonyms:
BSC, BSC2, NKCC1, PPP1R141, solute carrier family 12 member 2, basolateral Na-K-Cl symporter, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1, protein phosphatase 1, regulatory subunit 141, solute carrier family 12 (sodium/potassium/chloride transporter), member 2, solute carrier family 12 (sodium/potassium/chloride transporters), member 2
Genomic Location:
Chr 5: 127447382-127553279
Description:
The protein encoded by this gene mediates sodium and chloride transport and reabsorption. The encoded protein is a membrane protein and is important in maintaining proper ionic balance and cell volume. This protein is phosphorylated in response to DNA damage. Three transcript variants encoding two different isoforms have been found for this gene.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Bos taurus Danio rerio Pan troglodytes Canis lupus familiaris Gallus gallus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q23.3





GO Molecular Function

kinase binding | anion transmembrane transporter activity | ammonium transmembrane transporter activity | protein kinase binding | enzyme binding | transmembrane transporter activity | potassium:chloride symporter activity | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | sodium:potassium:chloride symporter activity | cation transmembrane transporter activity | active transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | sodium:chloride symporter activity | protein binding | metal ion transmembrane transporter activity | potassium ion transmembrane transporter activity | sodium ion transmembrane transporter activity | secondary active transmembrane transporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | cation:chloride symporter activity | solute:sodium symporter activity

GO Biological Process

hyperosmotic response | establishment of localization | anion transmembrane transporter activity | cellular process | gamma-aminobutyric acid signaling pathway | ammonium transmembrane transporter activity | localization | cellular homeostasis | metal ion transport | anion transport | transepithelial transport | regulation of cellular process | transmembrane transporter activity | cellular component organization | chloride transmembrane transport | response to stimulus | response to stress | chloride transport | potassium:chloride symporter activity | inorganic anion transport | G-protein coupled receptor signaling pathway | regulation of cellular component size | inorganic anion transmembrane transporter activity | symporter activity | metal ion homeostasis | chloride transmembrane transporter activity | potassium ion import | sodium:potassium:chloride symporter activity | ion transmembrane transport | sodium ion transport | cation transmembrane transporter activity | monovalent inorganic cation transport | transepithelial chloride transport | active transmembrane transporter activity | cellular potassium ion transport | ion transmembrane transporter activity | potassium ion transport | transepithelial ammonium transport | response to osmotic stress | cation homeostasis | cell communication | potassium ion homeostasis | homeostatic process | sodium:chloride symporter activity | cation transmembrane transport | metal ion transmembrane transporter activity | anion transmembrane transport | potassium ion transmembrane transporter activity | chemical homeostasis | ammonium transmembrane transport | sodium ion transmembrane transport | ion homeostasis | sodium ion transmembrane transporter activity | positive regulation of cell volume | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | transmembrane transport | signaling | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | regulation of cell size | cation transport | ammonium transport | developmental process | potassium ion transmembrane transport | cation:chloride symporter activity | ion transport | aging | cell volume homeostasis | signal transduction | solute:sodium symporter activity

GO Cellular Component

integral component of membrane | apical plasma membrane | cell | intrinsic component of membrane | apical part of cell | plasma membrane | vesicle | extracellular exosome | integral component of plasma membrane | extracellular region | membrane-bounded organelle | extracellular vesicle | organelle | extracellular space | cell periphery | membrane | intrinsic component of plasma membrane