QuickView for SLC18A1 (gene)

Gene Symbol:

SLC18A1 Homo sapiens

Full name:

solute carrier family 18 member A1

Synonyms:

CGAT, VAT1, VMAT1, chromaffin granule amine transporter, solute carrier family 18 (vesicular monoamine transporter), member 1, solute carrier family 18 (vesicular monoamine), member 1, solute carrier family 18 member 1, vesicular amine transporter 1

Genomic Location:

Chr 8: 20046652-20084997

Description:

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of actio...

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The vesicular monoamine transporter acts to accumulate cytosolic monoamines into vesicles, using the proton gradient maintained across the vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (Peter et al., 1993 [PubMed 7905859]). See also SLC18A2 (MIM 193001).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA_Q6 ,  GATA_C ,  CAGGTA_AREB6_01 ,  GATA6_01 ,  AR_Q2 ,  GATA1_05

Cytogenetic Map:

8p21.3

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