QuickView for SLC18A2 (gene)

Gene Symbol:

SLC18A2 Homo sapiens

Full name:

solute carrier family 18 member A2

Synonyms:

SVAT, SVMT, VAT2, VMAT2, synaptic vesicular amine transporter, monoamine neurotransmitter transporter, monoamine transporter, solute carrier family 18 (vesicular monoamine transporter), member 2, solute carrier family 18 (vesicular monoamine), member 2, solute carrier family 18 member 2, vesicle monoamine transporter type 2, vesicle monoamine/H+ antiporter, vesicular amine transporter 2

Genomic Location:

Chr 10: 118990706-119027085

Description:

The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter ...

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The vesicular monoamine transporter acts to accumulate cytosolic monoamines into synaptic vesicles, using the proton gradient maintained across the synaptic vesicular membrane. Its proper function is essential to the correct activity of the monoaminergic systems that have been implicated in several human neuropsychiatric disorders. The transporter is a site of action of important drugs, including reserpine and tetrabenazine (summary by Peter et al., 1993 [PubMed 7905859]). See also SLC18A1 (MIM 193002).

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Danio rerio ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  GTGTTGA_MIR505 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  ATF4_Q2 ,  ACTTTAT_MIR1425P ,  HNF1_C ,  PBX1_01 ,  CREB_Q4 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  PXR_Q2 ,  ATF3_Q6 ,  E4F1_Q6 ,  RORA1_01 ,  TTGTTT_FOXO4_01 ,  ATF1_Q6 ,  AFP1_Q6 ,  CREB_Q2 ,  TGACGTCA_ATF3_Q6 ,  RORA2_01 ,  TGACATY_UNKNOWN ,  CREB_Q2_01 ,  CREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-505

Cytogenetic Map:

10q25.3

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