QuickView for SLC25A13 (gene)

Gene Symbol:

SLC25A13 Homo sapiens

Full name:

solute carrier family 25 member 13

Synonyms:

ARALAR2, CITRIN, CTLN2, calcium-binding mitochondrial carrier protein Aralar2, mitochondrial aspartate glutamate carrier 2, solute carrier family 25 (aspartate/glutamate carrier), member 13

Genomic Location:

Chr 7: 95587468-95789341

Description:

This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of t...

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This gene is a member of the mitochondrial carrier family. The encoded protein contains four EF-hand Ca(2+) binding motifs in the N-terminal domain, and localizes to mitochondria. The protein catalyzes the exchange of aspartate for glutamate and a proton across the inner mitochondrial membrane, and is stimulated by calcium on the external side of the inner mitochondrial membrane. Mutations in this gene result in citrullinemia, type II. Multiple transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_07 ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  TGACCTY_ERR1_Q2 ,  WTGAAAT_UNKNOWN ,  CACCCBINDINGFACTOR_Q6 ,  NFY_Q6_01 ,  ALPHACP1_01 ,  YY1_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  PTF1BETA_Q6 ,  WTTGKCTG_UNKNOWN ,  AAACCAC_MIR140 ,  PPAR_DR1_Q2 ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-140

Cytogenetic Map:

7q21.3

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