QuickView for SLC29A1 (gene)

Gene Symbol:

SLC29A1 Homo sapiens

Full name:

solute carrier family 29 member 1 (Augustine blood group)

Synonyms:

ENT1, equilibrative nucleoside transporter 1, equilibrative nitrobenzylmercaptopurine riboside (NBMPR)-sensitive nucleoside transporter, nucleoside transporter, es-type, solute carrier family 29 (equilibrative nucleoside transporter), member 1, solute carrier family 29 (nucleoside transporters), member 1

Genomic Location:

Chr 6: 44295220-44309866

Description:

This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is...

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This gene is a member of the equilibrative nucleoside transporter family. The gene encodes a transmembrane glycoprotein that localizes to the plasma and mitochondrial membranes and mediates the cellular uptake of nucleosides from the surrounding medium. The protein is categorized as an equilibrative (as opposed to concentrative) transporter that is sensitive to inhibition by nitrobenzylthioinosine (NBMPR). Nucleoside transporters are required for nucleotide synthesis in cells that lack de novo nucleoside synthesis pathways, and are also necessary for the uptake of cytotoxic nucleosides used for cancer and viral chemotherapies. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

DBP_Q6 ,  TGTTTGY_HNF3_Q6 ,  GTGCCTT_MIR506

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-124a

Cytogenetic Map:

6p21.1

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