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QuickView for SLC30A10 (gene)


Gene Symbol:
SLC30A10 Homo sapiens Homo sapiens
Full name:
solute carrier family 30 member 10
Synonyms:
HMDPC, HMNDYT1, ZNT10, ZNT8, ZRC1, ZnT-10, zinc transporter 10, manganese transporter SLC30A10, zinc transporter 8
Genomic Location:
Chr 1: 218154229-218168616
Description:
This gene is highly expressed in the liver and is inducible by manganese. Its protein product appears to be critical in maintaining manganese levels, and has higher specificity for manganese than zinc. Loss of function mutations appear to result in a pleomorphic phenotype, including dystonia and adult-onset parkinsonism. Alternatively spliced trans...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Cytogenetic Map:
chr 1
1q41





GO Molecular Function

transition metal ion transmembrane transporter activity | transmembrane transporter activity | manganese ion transmembrane transporter activity | cation transmembrane transporter activity | transporter activity | ion transmembrane transporter activity | protein binding | metal ion transmembrane transporter activity | inorganic cation transmembrane transporter activity

GO Biological Process

regulation of ERK1 and ERK2 cascade | transition metal ion transmembrane transporter activity | regulation of localization | regulation of programmed cell death | regulation of cell aging | establishment of localization | response to hormone | negative regulation of neuron death | negative regulation of cellular process | positive regulation of phosphate metabolic process | regulation of neuron death | cellular process | localization | metal ion transport | negative regulation of apoptotic process | transition metal ion transport | positive regulation of nitrogen compound metabolic process | zinc ion transport | negative regulation of cellular metabolic process | response to peptide hormone | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | transmembrane transporter activity | epidermal growth factor receptor signaling pathway | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | response to stimulus | positive regulation of protein metabolic process | response to peptide | divalent metal ion transport | ERBB signaling pathway | negative regulation of metabolic process | negative regulation of reactive oxygen species biosynthetic process | manganese ion transmembrane transporter activity | regulation of cellular response to stress | response to nitrogen compound | negative regulation of neuron apoptotic process | cellular response to hormone stimulus | regulation of signal transduction | cellular response to peptide hormone stimulus | regulation of MAPK cascade | regulation of phosphorylation | ion transmembrane transport | zinc ion transmembrane transport | cellular response to peptide | cation transmembrane transporter activity | manganese ion transport | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of nitrogen compound metabolic process | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | ion transmembrane transporter activity | regulation of cellular protein metabolic process | cellular response to angiotensin | cell communication | regulation of cellular metabolic process | regulation of neuron apoptotic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of protein phosphorylation | response to angiotensin | cation transmembrane transport | positive regulation of protein modification process | response to organic substance | metal ion transmembrane transporter activity | regulation of intracellular signal transduction | cell surface receptor signaling pathway | negative regulation of programmed cell death | regulation of cellular response to manganese ion | negative regulation of biosynthetic process | positive regulation of ERK1 and ERK2 cascade | manganese ion transmembrane transport | regulation of phosphate metabolic process | inorganic cation transmembrane transport | negative regulation of cell aging | positive regulation of MAPK cascade | regulation of reactive oxygen species biosynthetic process | regulation of cell communication | transmembrane transport | negative regulation of cellular senescence | signaling | inorganic cation transmembrane transporter activity | positive regulation of phosphorylation | cation transport | regulation of developmental process | regulation of ion transport | regulation of transport | regulation of zinc ion transport | regulation of reactive oxygen species metabolic process | response to organonitrogen compound | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | ion transport | cellular response to organic substance | regulation of cell death | negative regulation of cell death | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | signal transduction | regulation of signaling | regulation of cellular senescence | regulation of phosphorus metabolic process

GO Cellular Component

integral component of membrane | intracellular membrane-bounded organelle | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | Golgi apparatus | recycling endosome | endomembrane system | plasma membrane | vesicle | endosome | membrane-bounded organelle | organelle | cell periphery | early endosome | intracellular vesicle | intracellular | membrane