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QuickView for SLC6A4 (gene)


Gene Symbol:
SLC6A4 Homo sapiens Homo sapiens
Full name:
solute carrier family 6 member 4
Synonyms:
5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Genomic Location:
Chr 17: 25549032-25586841
Description:
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the...
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q11.2


Transcripts Names
NM_001045
Protein Names
P31645
Q5EE02
B2R7Y7



GO Molecular Function

actin binding | actin filament binding | GTPase binding | anion transmembrane transporter activity | cation binding | ammonium transmembrane transporter activity | neurotransmitter transporter activity | neurotransmitter binding | enzyme binding | protein-containing complex binding | syntaxin binding | transmembrane transporter activity | cocaine binding | myosin binding | serotonin binding | Ras GTPase binding | inorganic anion transmembrane transporter activity | symporter activity | chloride transmembrane transporter activity | cytoskeletal protein binding | cation transmembrane transporter activity | serotonin:sodium symporter activity | active transmembrane transporter activity | transporter activity | identical protein binding | ion transmembrane transporter activity | ion binding | organic cyclic compound binding | amine binding | sodium:chloride symporter activity | protein binding | protein homodimerization activity | metal ion transmembrane transporter activity | protein dimerization activity | nitric-oxide synthase binding | sodium ion transmembrane transporter activity | small GTPase binding | secondary active transmembrane transporter activity | Rab GTPase binding | monoamine transmembrane transporter activity | SNARE binding | neurotransmitter:sodium symporter activity | inorganic cation transmembrane transporter activity | monovalent inorganic cation transmembrane transporter activity | drug binding | cation:chloride symporter activity | syntaxin-1 binding | metal ion binding | heterocyclic compound binding | solute:sodium symporter activity

GO Biological Process

response to extracellular stimulus | brain development | protein homooligomerization | regulation of blood vessel diameter | response to nutrient levels | serotonin uptake | regulation of neurogenesis | response to cGMP | regulation of cell development | regulation of localization | insemination | establishment of localization | response to hormone | anion transmembrane transporter activity | negative regulation of cellular process | social behavior | cell differentiation | negative regulation of organ growth | nervous system development | neurogenesis | generation of neurons | response to organophosphorus | cellular process | ammonium transmembrane transporter activity | localization | negative regulation of signaling | metal ion transport | negative regulation of developmental growth | response to estradiol | neurotransmitter transporter activity | anion transport | multicellular organismal reproductive process | response to hypoxia | regulation of cell cycle | establishment of localization in cell | regulation of cell differentiation | cellular response to retinoic acid | regulation of cellular process | cellular response to lipid | regulation of metabolic process | transmembrane transporter activity | negative regulation of synaptic transmission, dopaminergic | cellular response to organonitrogen compound | cellular component organization | head development | chloride transmembrane transport | response to stimulus | regulation of blood vessel size | response to stress | regulation of cell proliferation | chloride transport | circadian rhythm | inorganic anion transport | reproduction | cellular localization | organic hydroxy compound transport | rhythmic process | cellular response to organic cyclic compound | blood circulation | brain morphogenesis | cellular component assembly | modulation of chemical synaptic transmission | cellular biosynthetic process | inorganic anion transmembrane transporter activity | symporter activity | negative regulation of blood vessel diameter | regulation of neurotransmitter levels | response to nitrogen compound | system development | response to oxygen levels | reproductive process | negative regulation of growth | multicellular organism development | chloride transmembrane transporter activity | response to purine-containing compound | learning or memory | protein complex oligomerization | ion transmembrane transport | positive regulation of serotonin secretion | positive regulation of cell cycle | regulation of neuron differentiation | regulation of gene expression | positive regulation of secretion | organic substance transport | response to lipid | nervous system process | copulation | sodium ion transport | cation transmembrane transporter activity | serotonin:sodium symporter activity | monovalent inorganic cation transport | animal organ morphogenesis | active transmembrane transporter activity | response to nutrient | ion transmembrane transporter activity | regulation of synaptic transmission, dopaminergic | cognition | neurotransmitter metabolic process | biosynthetic process | vasoconstriction | response to toxic substance | regulation of serotonin secretion | regulation of thalamus size | serotonin transport | regulation of tube size | positive regulation of transport | response to retinoic acid | sodium:chloride symporter activity | sperm ejaculation | multicellular organism reproduction | cation transmembrane transport | protein-containing complex assembly | regulation of growth | response to organic substance | import into cell | metal ion transmembrane transporter activity | anion transmembrane transport | anatomical structure development | regulation of neural precursor cell proliferation | metabolic process | neurotransmitter uptake | negative regulation of cerebellar granule cell precursor proliferation | regulation of tube diameter | regulation of secretion | behavior | ammonium transmembrane transport | cellular response to cGMP | sodium ion transmembrane transport | mating | animal organ development | positive regulation of ion transport | negative regulation of neuron differentiation | sodium ion transmembrane transporter activity | inorganic cation transmembrane transport | secondary active transmembrane transporter activity | memory | monoamine transmembrane transporter activity | neurotransmitter biosynthetic process | neurotransmitter:sodium symporter activity | regulation of cell communication | transmembrane transport | inorganic cation transmembrane transporter activity | response to organic cyclic compound | monovalent inorganic cation transmembrane transporter activity | regulation of developmental growth | anatomical structure morphogenesis | cation transport | regulation of organ growth | regulation of cerebellar granule cell precursor proliferation | ammonium transport | regulation of nervous system development | regulation of developmental process | regulation of ion transport | developmental process | monoamine transport | regulation of transport | negative regulation of cell proliferation | negative regulation of neural precursor cell proliferation | neurotransmitter transport | response to organonitrogen compound | cation:chloride symporter activity | negative regulation of synaptic transmission | central nervous system development | positive regulation of metabolic process | ion transport | cellular metabolic process | cellular response to organic substance | negative regulation of cell development | sexual reproduction | negative regulation of cell differentiation | regulation of signaling | positive regulation of gene expression | negative regulation of neurogenesis | solute:sodium symporter activity | multicellular organismal process

GO Cellular Component

integral component of membrane | synapse | neuron projection | organelle membrane | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | membrane microdomain | presynapse | endosome membrane | cell projection | endomembrane system | plasma membrane | membrane raft | vesicle | integral component of plasma membrane | endosome | membrane-bounded organelle | organelle | cell periphery | cytosol | intracellular vesicle | intracellular | membrane | intrinsic component of plasma membrane