QuickView for SLC8A1 (gene)

Gene Symbol:

SLC8A1 Homo sapiens

Full name:

solute carrier family 8 member A1

Synonyms:

NCX1, sodium/calcium exchanger 1, Na(+)/Ca(2+)-exchange protein 1, Na+/Ca++ exchanger, Na+/Ca2+ exchanger, solute carrier family 8 (sodium/calcium exchanger), member 1, solute carrier family 8 member 1

Genomic Location:

Chr 2: 40192790-40510948

Description:

In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, ...

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In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also enters the cell through the sarcolemma (plasma membrane). During relaxation, Ca(2+) is sequestered within the intracellular stores. To prevent overloading of intracellular stores, the Ca(2+) that entered across the sarcolemma must be extruded from the cell. The Na(+)-Ca(2+) exchanger is the primary mechanism by which the Ca(2+) is extruded from the cell during relaxation. In the heart, the exchanger may play a key role in digitalis action. The exchanger is the dominant mechanism in returning the cardiac myocyte to its resting state following excitation.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TTANTCA_UNKNOWN ,  AACTGAC_MIR223 ,  OSF2_Q6

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-223 ,  Predicted Gene Targets for miR-410

Cytogenetic Map:

2p22.1

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